PMID- 19111660
OWN - NLM
STAT- MEDLINE
DCOM- 20090123
LR  - 20220330
IS  - 1097-4164 (Electronic)
IS  - 1097-2765 (Linking)
VI  - 32
IP  - 6
DP  - 2008 Dec 26
TI  - PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.
PG  - 803-14
LID - 10.1016/j.molcel.2008.11.019 [doi]
AB  - p73 has been identified as a structural and functional homolog of the tumor 
      suppressor p53. The transcriptional coactivator Yes-associated protein (YAP) has 
      been demonstrated to interact with and to enhance p73-dependent apoptosis in 
      response to DNA damage. Here, we show the existence of a proapoptotic 
      autoregulatory feedback loop between p73, YAP, and the promyelocytic leukemia 
      (PML) tumor suppressor gene. We demonstrate that PML is a direct transcriptional 
      target of p73/YAP, and we show that PML transcriptional activation by p73/YAP is 
      under the negative control of the proto-oncogenic Akt/PKB kinase. Importantly, we 
      find that PML and YAP physically interact through their PVPVY and WW domains, 
      respectively, causing PML-mediated sumoylation and stabilization of YAP. Hence, 
      we determine a mechanistic pathway in response to DNA damage that could have 
      relevant implications for the treatment of human cancer.
FAU - Lapi, Eleonora
AU  - Lapi E
AD  - Ludwig Institute for Cancer Research, University of Oxford Branch, Oxford OX3 
      7DQ, UK.
FAU - Di Agostino, Silvia
AU  - Di Agostino S
FAU - Donzelli, Sara
AU  - Donzelli S
FAU - Gal, Hilah
AU  - Gal H
FAU - Domany, Eytan
AU  - Domany E
FAU - Rechavi, Gideon
AU  - Rechavi G
FAU - Pandolfi, Pier Paolo
AU  - Pandolfi PP
FAU - Givol, David
AU  - Givol D
FAU - Strano, Sabrina
AU  - Strano S
FAU - Lu, Xin
AU  - Lu X
FAU - Blandino, Giovanni
AU  - Blandino G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Pml protein, mouse)
RN  - 0 (Promyelocytic Leukemia Protein)
RN  - 0 (Small Ubiquitin-Related Modifier Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 0 (Ubiquitin)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (YAP1 protein, human)
RN  - 0 (Yap1 protein, mouse)
RN  - 143220-95-5 (PML protein, human)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
CIN - Mol Cell. 2008 Dec 26;32(6):749-50. PMID: 19111652
MH  - Adaptor Proteins, Signal Transducing/*metabolism
MH  - Animals
MH  - *Apoptosis/drug effects
MH  - Cell Cycle Proteins
MH  - Cell Line
MH  - Cisplatin/pharmacology
MH  - DNA-Binding Proteins/*metabolism
MH  - *Feedback, Physiological/drug effects
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Humans
MH  - Mice
MH  - Models, Biological
MH  - Nuclear Proteins/genetics/*metabolism
MH  - Oligonucleotide Array Sequence Analysis
MH  - Phosphoproteins/*metabolism
MH  - Promyelocytic Leukemia Protein
MH  - Proteasome Endopeptidase Complex/metabolism
MH  - Protein Binding/drug effects
MH  - Protein Processing, Post-Translational/drug effects
MH  - Protein Stability/drug effects
MH  - Regulatory Sequences, Nucleic Acid/genetics
MH  - Small Ubiquitin-Related Modifier Proteins/metabolism
MH  - Transcription Factors/genetics/*metabolism
MH  - Transcription, Genetic/drug effects
MH  - Transcriptional Activation/drug effects
MH  - Tumor Suppressor Proteins/genetics/*metabolism
MH  - Ubiquitin/metabolism
MH  - YAP-Signaling Proteins
EDAT- 2008/12/30 09:00
MHDA- 2009/01/24 09:00
CRDT- 2008/12/30 09:00
PHST- 2008/05/13 00:00 [received]
PHST- 2008/09/24 00:00 [revised]
PHST- 2008/11/01 00:00 [accepted]
PHST- 2008/12/30 09:00 [entrez]
PHST- 2008/12/30 09:00 [pubmed]
PHST- 2009/01/24 09:00 [medline]
AID - S1097-2765(08)00841-1 [pii]
AID - 10.1016/j.molcel.2008.11.019 [doi]
PST - ppublish
SO  - Mol Cell. 2008 Dec 26;32(6):803-14. doi: 10.1016/j.molcel.2008.11.019.