PMID- 19289085
OWN - NLM
STAT- MEDLINE
DCOM- 20090402
LR  - 20240104
IS  - 1878-1551 (Electronic)
IS  - 1534-5807 (Linking)
VI  - 16
IP  - 3
DP  - 2009 Mar
TI  - The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to 
      distinguish mouse trophectoderm from inner cell mass.
PG  - 398-410
LID - 10.1016/j.devcel.2009.02.003 [doi]
AB  - Outside cells of the preimplantation mouse embryo form the trophectoderm (TE), a 
      process requiring the transcription factor Tead4. Here, we show that 
      transcriptionally active Tead4 can induce Cdx2 and other trophoblast genes in 
      parallel in embryonic stem cells. In embryos, the Tead4 coactivator protein Yap 
      localizes to nuclei of outside cells, and modulation of Tead4 or Yap activity 
      leads to changes in Cdx2 expression. In inside cells, Yap is phosphorylated and 
      cytoplasmic, and this involves the Hippo signaling pathway component Lats. We 
      propose that active Tead4 promotes TE development in outside cells, whereas Tead4 
      activity is suppressed in inside cells by cell contact- and Lats-mediated 
      inhibition of nuclear Yap localization. Thus, differential signaling between 
      inside and outside cell populations leads to changes in cell fate specification 
      during TE formation.
FAU - Nishioka, Noriyuki
AU  - Nishioka N
AD  - Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2-2-3 
      Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
FAU - Inoue, Ken-ichi
AU  - Inoue K
FAU - Adachi, Kenjiro
AU  - Adachi K
FAU - Kiyonari, Hiroshi
AU  - Kiyonari H
FAU - Ota, Mitsunori
AU  - Ota M
FAU - Ralston, Amy
AU  - Ralston A
FAU - Yabuta, Norikazu
AU  - Yabuta N
FAU - Hirahara, Shino
AU  - Hirahara S
FAU - Stephenson, Robert O
AU  - Stephenson RO
FAU - Ogonuki, Narumi
AU  - Ogonuki N
FAU - Makita, Ryosuke
AU  - Makita R
FAU - Kurihara, Hiroki
AU  - Kurihara H
FAU - Morin-Kensicki, Elizabeth M
AU  - Morin-Kensicki EM
FAU - Nojima, Hiroshi
AU  - Nojima H
FAU - Rossant, Janet
AU  - Rossant J
FAU - Nakao, Kazuki
AU  - Nakao K
FAU - Niwa, Hitoshi
AU  - Niwa H
FAU - Sasaki, Hiroshi
AU  - Sasaki H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Cell
JT  - Developmental cell
JID - 101120028
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (CDX2 Transcription Factor)
RN  - 0 (Cdx2 protein, mouse)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Muscle Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (TEA Domain Transcription Factors)
RN  - 0 (Tead4 protein, mouse)
RN  - 0 (Transcription Factors)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (Yap1 protein, mouse)
RN  - EC 2.7.1.- (Lats1 protein, mouse)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
CIN - Dev Cell. 2009 Mar;16(3):321-2. PMID: 19289076
CIN - Dev Cell. 2011 Mar 15;20(3):e3. PMID: 21411395
MH  - Adaptor Proteins, Signal Transducing/genetics/*metabolism
MH  - Animals
MH  - Blastocyst Inner Cell Mass/*metabolism
MH  - CDX2 Transcription Factor
MH  - Cell Cycle Proteins
MH  - Cells, Cultured
MH  - DNA-Binding Proteins/genetics/*metabolism
MH  - Ectoderm/metabolism
MH  - Embryo Culture Techniques
MH  - Embryonic Stem Cells/metabolism
MH  - Female
MH  - Gene Expression Regulation, Developmental
MH  - Homeodomain Proteins/genetics/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Mice, Mutant Strains
MH  - Mice, Transgenic
MH  - Models, Biological
MH  - Muscle Proteins/genetics/*metabolism
MH  - Phosphoproteins/genetics/*metabolism
MH  - Pregnancy
MH  - Protein Serine-Threonine Kinases/genetics/*metabolism
MH  - Signal Transduction
MH  - TEA Domain Transcription Factors
MH  - Transcription Factors/genetics/*metabolism
MH  - Trophoblasts/*metabolism
MH  - YAP-Signaling Proteins
EDAT- 2009/03/18 09:00
MHDA- 2009/04/03 09:00
CRDT- 2009/03/18 09:00
PHST- 2008/08/22 00:00 [received]
PHST- 2008/11/28 00:00 [revised]
PHST- 2009/02/06 00:00 [accepted]
PHST- 2009/03/18 09:00 [entrez]
PHST- 2009/03/18 09:00 [pubmed]
PHST- 2009/04/03 09:00 [medline]
AID - S1534-5807(09)00077-X [pii]
AID - 10.1016/j.devcel.2009.02.003 [doi]
PST - ppublish
SO  - Dev Cell. 2009 Mar;16(3):398-410. doi: 10.1016/j.devcel.2009.02.003.