PMID- 19305396
OWN - NLM
STAT- MEDLINE
DCOM- 20090605
LR  - 20211020
IS  - 1529-2916 (Electronic)
IS  - 1529-2908 (Linking)
VI  - 10
IP  - 5
DP  - 2009 May
TI  - C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the 
      choroid plexus is required for the initiation of EAE.
PG  - 514-23
LID - 10.1038/ni.1716 [doi]
AB  - Interleukin 17-producing T helper cells (T(H)-17 cells) are important in 
      experimental autoimmune encephalomyelitis, but their route of entry into the 
      central nervous system (CNS) and their contribution relative to that of other 
      effector T cells remain to be determined. Here we found that mice lacking CCR6, a 
      chemokine receptor characteristic of T(H)-17 cells, developed T(H)-17 responses 
      but were highly resistant to the induction of experimental autoimmune 
      encephalomyelitis. Disease susceptibility was reconstituted by transfer of 
      wild-type T cells that entered into the CNS before disease onset and triggered 
      massive CCR6-independent recruitment of effector T cells across activated 
      parenchymal vessels. The CCR6 ligand CCL20 was constitutively expressed in 
      epithelial cells of choroid plexus in mice and humans. Our results identify 
      distinct molecular requirements and ports of lymphocyte entry into uninflamed 
      versus inflamed CNS and suggest that the CCR6-CCL20 axis in the choroid plexus 
      controls immune surveillance of the CNS.
FAU - Reboldi, Andrea
AU  - Reboldi A
AD  - Institute for Research in Biomedicine, Bellinzona, Switzerland.
FAU - Coisne, Caroline
AU  - Coisne C
FAU - Baumjohann, Dirk
AU  - Baumjohann D
FAU - Benvenuto, Federica
AU  - Benvenuto F
FAU - Bottinelli, Denise
AU  - Bottinelli D
FAU - Lira, Sergio
AU  - Lira S
FAU - Uccelli, Antonio
AU  - Uccelli A
FAU - Lanzavecchia, Antonio
AU  - Lanzavecchia A
FAU - Engelhardt, Britta
AU  - Engelhardt B
FAU - Sallusto, Federica
AU  - Sallusto F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090322
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (CCR6 protein, mouse)
RN  - 0 (Chemokine CCL20)
RN  - 0 (Interleukin-17)
RN  - 0 (Receptors, CCR6)
SB  - IM
CIN - Nat Immunol. 2009 May;10(5):453-5. PMID: 19381137
MH  - Animals
MH  - Cell Differentiation/immunology
MH  - Chemokine CCL20
MH  - Chemotaxis, Leukocyte/immunology
MH  - Choroid Plexus/*immunology/metabolism
MH  - Encephalomyelitis, Autoimmune, Experimental/*immunology/metabolism
MH  - Female
MH  - Flow Cytometry
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunologic Surveillance
MH  - Interleukin-17/*immunology/metabolism
MH  - Lymphocyte Activation/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Multiple Sclerosis/immunology/metabolism
MH  - Receptors, CCR6/*immunology/metabolism
MH  - T-Lymphocytes, Helper-Inducer/cytology/*immunology/metabolism
EDAT- 2009/03/24 09:00
MHDA- 2009/06/06 09:00
CRDT- 2009/03/24 09:00
PHST- 2008/11/04 00:00 [received]
PHST- 2009/02/10 00:00 [accepted]
PHST- 2009/03/24 09:00 [entrez]
PHST- 2009/03/24 09:00 [pubmed]
PHST- 2009/06/06 09:00 [medline]
AID - ni.1716 [pii]
AID - 10.1038/ni.1716 [doi]
PST - ppublish
SO  - Nat Immunol. 2009 May;10(5):514-23. doi: 10.1038/ni.1716. Epub 2009 Mar 22.