PMID- 19344179
OWN - NLM
STAT- MEDLINE
DCOM- 20090702
LR  - 20240109
IS  - 1530-6992 (Electronic)
IS  - 1530-6984 (Linking)
VI  - 9
IP  - 5
DP  - 2009 May
TI  - Mediating tumor targeting efficiency of nanoparticles through design.
PG  - 1909-15
LID - 10.1021/nl900031y [doi]
AB  - Here we systematically examined the effect of nanoparticle size (10-100 nm) and 
      surface chemistry (i.e., poly(ethylene glycol)) on passive targeting of tumors in 
      vivo. We found that the physical and chemical properties of the nanoparticles 
      influenced their pharmacokinetic behavior, which ultimately determined their 
      tumor accumulation capacity. Interestingly, the permeation of nanoparticles 
      within the tumor is highly dependent on the overall size of the nanoparticle, 
      where larger nanoparticles appear to stay near the vasculature while smaller 
      nanoparticles rapidly diffuse throughout the tumor matrix. Our results provide 
      design parameters for engineering nanoparticles for optimized tumor targeting of 
      contrast agents and therapeutics.
FAU - Perrault, Steven D
AU  - Perrault SD
AD  - Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre 
      for Cellular and Biomolecular Research, University of Toronto, 160 College 
      Street, Toronto, ON, M5S 3E1, Canada.
FAU - Walkey, Carl
AU  - Walkey C
FAU - Jennings, Travis
AU  - Jennings T
FAU - Fischer, Hans C
AU  - Fischer HC
FAU - Chan, Warren C W
AU  - Chan WC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nano Lett
JT  - Nano letters
JID - 101088070
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Gold/*chemistry
MH  - Metal Nanoparticles/*chemistry
MH  - Mice
MH  - Neoplasms/*metabolism
MH  - Particle Size
MH  - Permeability
MH  - Polyethylene Glycols/*chemistry
MH  - Xenograft Model Antitumor Assays
EDAT- 2009/04/07 09:00
MHDA- 2009/07/03 09:00
CRDT- 2009/04/07 09:00
PHST- 2009/04/07 09:00 [entrez]
PHST- 2009/04/07 09:00 [pubmed]
PHST- 2009/07/03 09:00 [medline]
AID - 10.1021/nl900031y [doi]
PST - ppublish
SO  - Nano Lett. 2009 May;9(5):1909-15. doi: 10.1021/nl900031y.