PMID- 19629069
OWN - NLM
STAT- MEDLINE
DCOM- 20090811
LR  - 20240109
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Linking)
VI  - 9
IP  - 8
DP  - 2009 Aug
TI  - Signal integration by JNK and p38 MAPK pathways in cancer development.
PG  - 537-49
LID - 10.1038/nrc2694 [doi]
AB  - Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) 
      family members function in a cell context-specific and cell type-specific manner 
      to integrate signals that affect proliferation, differentiation, survival and 
      migration. Consistent with the importance of these events in tumorigenesis, JNK 
      and p38 MAPK signalling is associated with cancers in humans and mice. Studies in 
      mouse models have been essential to better understand how these MAPKs control 
      cancer development, and these models are expected to provide new strategies for 
      the design of improved therapeutic approaches. In this Review we highlight the 
      recent progress made in defining the functions of the JNK and p38 MAPK pathways 
      in different cancers.
FAU - Wagner, Erwin F
AU  - Wagner EF
AD  - Centro Nacional de Investigaciones Oncologicas, C/Melchor Fernandez Almagro 3, 
      Madrid 28029, Spain. ewagner@cnio.es
FAU - Nebreda, Angel R
AU  - Nebreda AR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Cell Proliferation
MH  - Disease Models, Animal
MH  - Humans
MH  - JNK Mitogen-Activated Protein Kinases/*physiology
MH  - MAP Kinase Signaling System/*physiology
MH  - Mice
MH  - Neoplasms/*etiology/*pathology/therapy
MH  - Receptor Cross-Talk
MH  - p38 Mitogen-Activated Protein Kinases/*physiology
RF  - 164
EDAT- 2009/07/25 09:00
MHDA- 2009/08/12 09:00
CRDT- 2009/07/25 09:00
PHST- 2009/07/25 09:00 [entrez]
PHST- 2009/07/25 09:00 [pubmed]
PHST- 2009/08/12 09:00 [medline]
AID - nrc2694 [pii]
AID - 10.1038/nrc2694 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2009 Aug;9(8):537-49. doi: 10.1038/nrc2694.