PMID- 19703435
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20091012
IS  - 1873-2941 (Electronic)
IS  - 0009-3084 (Linking)
VI  - 162
IP  - 1-2
DP  - 2009 Nov
TI  - Ultrasound, liposomes, and drug delivery: principles for using ultrasound to 
      control the release of drugs from liposomes.
PG  - 1-16
LID - 10.1016/j.chemphyslip.2009.08.003 [doi]
AB  - Ultrasound is used in many medical applications, such as imaging, blood flow 
      analysis, dentistry, liposuction, tumor and fibroid ablation, and kidney stone 
      disruption. In the past, low frequency ultrasound (LFUS) was the main method to 
      downsize multilamellar (micron range) vesicles into small (nano scale) 
      unilamellar vesicles. Recently, the ability of ultrasound to induce localized and 
      controlled drug release from liposomes, utilizing thermal and/or mechanical 
      effects, has been shown. This review, deals with the interaction of ultrasound 
      with liposomes, focusing mainly on the mechanical mechanism of drug release from 
      liposomes using LFUS. The effects of liposome lipid composition and 
      physicochemical properties, on one hand, and of LFUS parameters, on the other, on 
      liposomal drug release, are addressed. Acoustic cavitation, in which gas bubbles 
      oscillate and collapse in the medium, thereby introducing intense mechanical 
      strains, increases release substantially. We suggest that the mechanism of 
      release may involve formation and collapse of small gas nuclei in the hydrophobic 
      region of the lipid bilayer during exposure to LFUS, thereby inducing the 
      formation of transient pores through which drugs are released. Introducing 
      PEG-lipopolymers to the liposome bilayer enhances responsivity to LFUS, most 
      likely due to absorption of ultrasonic energy by the highly hydrated PEG 
      headgroups. The presence of amphiphiles, such as phospholipids with unsaturated 
      acyl chains, which destabilize the lipid bilayer, also increases liposome 
      susceptibility to LFUS. Application of these principles to design highly 
      LFUS-responsive liposomes is discussed.
FAU - Schroeder, Avi
AU  - Schroeder A
AD  - Laboratory of Liposome and Membrane Research, Department of Biochemistry, Hebrew 
      University-Hadassah Medical School, Jerusalem 91120, Israel.
FAU - Kost, Joseph
AU  - Kost J
FAU - Barenholz, Yechezkel
AU  - Barenholz Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090822
PL  - Ireland
TA  - Chem Phys Lipids
JT  - Chemistry and physics of lipids
JID - 0067206
RN  - 0 (Drug Carriers)
RN  - 0 (Lipid Bilayers)
RN  - 0 (Liposomes)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Animals
MH  - Drug Carriers/*chemistry/metabolism
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Lipid Bilayers/chemistry/metabolism
MH  - Liposomes/*chemistry/metabolism
MH  - Pharmaceutical Preparations/*chemistry/metabolism
MH  - Surface Properties
MH  - *Ultrasonics
RF  - 234
EDAT- 2009/08/26 09:00
MHDA- 2010/03/10 06:00
CRDT- 2009/08/26 09:00
PHST- 2009/03/25 00:00 [received]
PHST- 2009/08/17 00:00 [revised]
PHST- 2009/08/18 00:00 [accepted]
PHST- 2009/08/26 09:00 [entrez]
PHST- 2009/08/26 09:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - S0009-3084(09)00311-9 [pii]
AID - 10.1016/j.chemphyslip.2009.08.003 [doi]
PST - ppublish
SO  - Chem Phys Lipids. 2009 Nov;162(1-2):1-16. doi: 10.1016/j.chemphyslip.2009.08.003. 
      Epub 2009 Aug 22.