PMID- 19740640
OWN - NLM
STAT- MEDLINE
DCOM- 20100305
LR  - 20091202
IS  - 1879-0410 (Electronic)
IS  - 0955-0674 (Linking)
VI  - 21
IP  - 6
DP  - 2009 Dec
TI  - Cytoskeletal control of growth and cell fate switching.
PG  - 864-70
LID - 10.1016/j.ceb.2009.08.001 [doi]
AB  - Living cells must be able to switch between growth and differentiation with high 
      fidelity and precise spatial control to ensure that normal tissue patterns are 
      formed in the embryo and maintained throughout adult life. Most work on cell 
      proliferation focuses on elucidating the signaling pathways responsible for 
      control of cell cycle progression that are triggered by cell binding to soluble 
      growth factors and insoluble extracellular matrix. Here we review recent work, 
      which has revealed that mechanical tension-dependent changes in cell shape and 
      cytoskeletal structure are equally critical for control of growth, as well as 
      cell fate switching. This interplay between soluble, insoluble, and mechanical 
      cues helps to explain how cell behaviors responsible for tissue formation are 
      controlled in the physical context of living tissues.
FAU - Mammoto, Akiko
AU  - Mammoto A
AD  - Vascular Biology Program, Department of Surgery, Harvard Medical School and 
      Children's Hospital, Boston, MA 02115, USA.
FAU - Ingber, Donald E
AU  - Ingber DE
LA  - eng
GR  - CA045548/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090908
PL  - England
TA  - Curr Opin Cell Biol
JT  - Current opinion in cell biology
JID - 8913428
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Animals
MH  - Cell Cycle/physiology
MH  - Cell Cycle Proteins/metabolism
MH  - Cell Differentiation
MH  - *Cell Proliferation
MH  - Cytoskeleton/*metabolism
MH  - Embryonic Development
MH  - Extracellular Matrix/metabolism
MH  - Growth/physiology
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/metabolism
RF  - 57
EDAT- 2009/09/11 06:00
MHDA- 2010/03/06 06:00
CRDT- 2009/09/11 06:00
PHST- 2009/07/10 00:00 [received]
PHST- 2009/08/10 00:00 [accepted]
PHST- 2009/09/11 06:00 [entrez]
PHST- 2009/09/11 06:00 [pubmed]
PHST- 2010/03/06 06:00 [medline]
AID - S0955-0674(09)00148-3 [pii]
AID - 10.1016/j.ceb.2009.08.001 [doi]
PST - ppublish
SO  - Curr Opin Cell Biol. 2009 Dec;21(6):864-70. doi: 10.1016/j.ceb.2009.08.001. Epub 
      2009 Sep 8.