PMID- 19751618
OWN - NLM
STAT- MEDLINE
DCOM- 20091207
LR  - 20211028
IS  - 1096-3634 (Electronic)
IS  - 1084-9521 (Linking)
VI  - 20
IP  - 8
DP  - 2009 Oct
TI  - Asymmetric localisation of planar polarity proteins: Mechanisms and consequences.
PG  - 957-63
LID - 10.1016/j.semcdb.2009.03.006 [doi]
AB  - Planar polarisation of tissues is essential for many aspects of developmental 
      patterning. It is regulated by a conserved group of core planar polarity 
      proteins, which localise asymmetrically within cells prior to morphological signs 
      of polarisation. A subset of these core proteins also interact across cell 
      boundaries, mediating intercellular communication that co-ordinates polarity 
      between neighbouring cells. Core protein localisation subsequently mediates 
      changes in the actin cytoskeleton which lead to overt polarisation. In this 
      review we discuss the mechanisms by which the core planar polarity proteins 
      become asymmetrically localised, and the significance of this subcellular 
      localisation for both intercellular communication and downstream effects on the 
      cytoskeleton.
FAU - Strutt, Helen
AU  - Strutt H
AD  - MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical 
      Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, 
      UK. h.strutt@sheffield.ac.uk
FAU - Strutt, David
AU  - Strutt D
LA  - eng
GR  - 084469/WT_/Wellcome Trust/United Kingdom
GR  - MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090321
PL  - England
TA  - Semin Cell Dev Biol
JT  - Seminars in cell & developmental biology
JID - 9607332
RN  - 0 (Proteins)
SB  - IM
MH  - Animals
MH  - *Cell Communication
MH  - *Cell Polarity
MH  - Extracellular Space/metabolism
MH  - Protein Transport
MH  - Proteins/*metabolism
MH  - Signal Transduction
RF  - 51
EDAT- 2009/09/16 06:00
MHDA- 2009/12/16 06:00
CRDT- 2009/09/16 06:00
PHST- 2008/11/21 00:00 [received]
PHST- 2009/03/02 00:00 [revised]
PHST- 2009/03/12 00:00 [accepted]
PHST- 2009/09/16 06:00 [entrez]
PHST- 2009/09/16 06:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - S1084-9521(09)00044-5 [pii]
AID - 10.1016/j.semcdb.2009.03.006 [doi]
PST - ppublish
SO  - Semin Cell Dev Biol. 2009 Oct;20(8):957-63. doi: 10.1016/j.semcdb.2009.03.006. 
      Epub 2009 Mar 21.