PMID- 19760641
OWN - NLM
STAT- MEDLINE
DCOM- 20100809
LR  - 20211020
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Print)
IS  - 0730-2312 (Linking)
VI  - 108
IP  - 5
DP  - 2009 Dec 1
TI  - Cancer stem cells: cell culture, markers, and targets for new therapies.
PG  - 1031-8
LID - 10.1002/jcb.22350 [doi]
AB  - A cancer stem cell (CSC) is defined as an undifferentiated cell with the ability 
      to self-renew, differentiate to multiple lineages and initiate tumors that mimic 
      the parent tumor. In this review, we focus on glioblastomas, describing recent 
      progress and problems in characterizing these cells. There have been advances in 
      CSC culture, but tumor cell heterogeneity has made purification of CSCs 
      difficult. Indeed, it may be that CSCs significantly vary from tumor to tumor. We 
      also discuss the proposal that CSCs are resistant to radiotherapy and 
      chemotherapy and play a major role in repopulating tumors following treatment. To 
      overcome their resistance to conventional therapies, we may be able to use our 
      extensive knowledge of the signaling pathways essential for stem cells during 
      development. These pathways have potential as targets for new glioblastoma 
      therapies. Hence, although there is an ongoing debate on the nature of CSCs, the 
      theory continues to suggest new ideas for both the lab and the clinic.
FAU - Gilbert, Candace A
AU  - Gilbert CA
AD  - Department of Biochemistry and Molecular Pharmacology, University of 
      Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
FAU - Ross, Alonzo H
AU  - Ross AH
LA  - eng
GR  - R01 NS021716/NS/NINDS NIH HHS/United States
GR  - R01 NS021716-24/NS/NINDS NIH HHS/United States
GR  - NS021716/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Culture Media)
SB  - IM
MH  - *Biomarkers, Tumor
MH  - Brain Neoplasms/drug therapy/pathology/radiotherapy
MH  - Cell Culture Techniques
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Cell Proliferation
MH  - Cell Transformation, Neoplastic
MH  - Culture Media
MH  - Drug Resistance, Neoplasm/physiology
MH  - Glioblastoma/drug therapy/pathology/radiotherapy
MH  - Humans
MH  - Models, Biological
MH  - *Neoplastic Stem Cells/pathology/physiology
MH  - Signal Transduction/physiology
PMC - PMC2909872
MID - NIHMS219059
EDAT- 2009/09/18 06:00
MHDA- 2010/08/10 06:00
PMCR- 2010/12/01
CRDT- 2009/09/18 06:00
PHST- 2009/09/18 06:00 [entrez]
PHST- 2009/09/18 06:00 [pubmed]
PHST- 2010/08/10 06:00 [medline]
PHST- 2010/12/01 00:00 [pmc-release]
AID - 10.1002/jcb.22350 [doi]
PST - ppublish
SO  - J Cell Biochem. 2009 Dec 1;108(5):1031-8. doi: 10.1002/jcb.22350.