PMID- 19763153
OWN - NLM
STAT- MEDLINE
DCOM- 20091008
LR  - 20240321
IS  - 1471-0064 (Electronic)
IS  - 1471-0056 (Print)
IS  - 1471-0056 (Linking)
VI  - 10
IP  - 10
DP  - 2009 Oct
TI  - Causes and consequences of microRNA dysregulation in cancer.
PG  - 704-14
LID - 10.1038/nrg2634 [doi]
AB  - Over the past several years it has become clear that alterations in the 
      expression of microRNA (miRNA) genes contribute to the pathogenesis of most--if 
      not all--human malignancies. These alterations can be caused by various 
      mechanisms, including deletions, amplifications or mutations involving miRNA 
      loci, epigenetic silencing or the dysregulation of transcription factors that 
      target specific miRNAs. Because malignant cells show dependence on the 
      dysregulated expression of miRNA genes, which in turn control or are controlled 
      by the dysregulation of multiple protein-coding oncogenes or tumour suppressor 
      genes, these small RNAs provide important opportunities for the development of 
      future miRNA-based therapies.
FAU - Croce, Carlo M
AU  - Croce CM
AD  - Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State 
      University Medical Center, 410 West 10th Avenue, Columbus, OH 43210, USA. 
      carlo.croce@osumc.edu
LA  - eng
GR  - P01 CA076259/CA/NCI NIH HHS/United States
GR  - P01 CA076259-050001/CA/NCI NIH HHS/United States
GR  - P01 CA129242/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nat Rev Genet
JT  - Nature reviews. Genetics
JID - 100962779
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation, Neoplastic/*physiology
MH  - Humans
MH  - MicroRNAs/*genetics
MH  - Neoplasms/*genetics
PMC - PMC3467096
MID - NIHMS197508
EDAT- 2009/09/19 06:00
MHDA- 2009/10/09 06:00
PMCR- 2012/10/09
CRDT- 2009/09/19 06:00
PHST- 2009/09/19 06:00 [entrez]
PHST- 2009/09/19 06:00 [pubmed]
PHST- 2009/10/09 06:00 [medline]
PHST- 2012/10/09 00:00 [pmc-release]
AID - nrg2634 [pii]
AID - 10.1038/nrg2634 [doi]
PST - ppublish
SO  - Nat Rev Genet. 2009 Oct;10(10):704-14. doi: 10.1038/nrg2634.