PMID- 19778508
OWN - NLM
STAT- MEDLINE
DCOM- 20091009
LR  - 20231120
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 63
IP  - 6
DP  - 2009 Sep 24
TI  - The microRNA bantam functions in epithelial cells to regulate scaling growth of 
      dendrite arbors in drosophila sensory neurons.
PG  - 788-802
LID - 10.1016/j.neuron.2009.08.006 [doi]
AB  - In addition to establishing dendritic coverage of the receptive field, neurons 
      need to adjust their dendritic arbors to match changes of the receptive field. 
      Here, we show that dendrite arborization (da) sensory neurons establish dendritic 
      coverage of the body wall early in Drosophila larval development and then grow in 
      precise proportion to their substrate, the underlying body wall epithelium, as 
      the larva more than triples in length. This phenomenon, referred to as scaling 
      growth of dendrites, requires the function of the microRNA (miRNA) bantam (ban) 
      in the epithelial cells rather than the da neurons themselves. We further show 
      that ban in epithelial cells dampens Akt kinase activity in adjacent neurons to 
      influence dendrite growth. This signaling between epithelial cells and neurons 
      receiving sensory input from the body wall synchronizes their growth to ensure 
      proper dendritic coverage of the receptive field.
FAU - Parrish, Jay Z
AU  - Parrish JZ
AD  - Howard Hughes Medical Institute, Departments of Physiology, Biochemistry, and 
      Biophysics, University of California, San Francisco, San Francisco, CA 94158, 
      USA.
FAU - Xu, Peizhang
AU  - Xu P
FAU - Kim, Charles C
AU  - Kim CC
FAU - Jan, Lily Yeh
AU  - Jan LY
FAU - Jan, Yuh Nung
AU  - Jan YN
LA  - eng
GR  - K99 MH084277-02/MH/NIMH NIH HHS/United States
GR  - R37 NS040929/NS/NINDS NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - R01 MH084234/MH/NIMH NIH HHS/United States
GR  - R01 MH084234-06/MH/NIMH NIH HHS/United States
GR  - 5K99MH084277/MH/NIMH NIH HHS/United States
GR  - R01 NS040929/NS/NINDS NIH HHS/United States
GR  - R01 NS040929-09/NS/NINDS NIH HHS/United States
GR  - K99 MH084277/MH/NIMH NIH HHS/United States
GR  - R01NS40929/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Drosophila Proteins)
RN  - 0 (MicroRNAs)
RN  - 0 (bantam microRNA, Drosophila)
RN  - 0 (enhanced green fluorescent protein)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - EC 1.11.1.- (Horseradish Peroxidase)
RN  - EC 2.7.11.1 (Oncogene Protein v-akt)
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Dendrites/*pathology/*physiology
MH  - Drosophila/embryology/growth & development
MH  - Drosophila Proteins/genetics/metabolism
MH  - Embryo, Nonmammalian
MH  - Epithelial Cells/cytology/*metabolism
MH  - Gene Expression Regulation, Developmental/genetics/*physiology
MH  - Green Fluorescent Proteins/genetics
MH  - Horseradish Peroxidase/metabolism
MH  - Larva
MH  - Laser Therapy/methods
MH  - MicroRNAs/*physiology
MH  - Mutation/genetics
MH  - Oncogene Protein v-akt/metabolism
MH  - Peripheral Nerves/cytology
MH  - Sensory Receptor Cells/*cytology
MH  - Signal Transduction/genetics
MH  - Time Factors
PMC - PMC2772869
MID - NIHMS149998
EDAT- 2009/09/26 06:00
MHDA- 2009/10/10 06:00
PMCR- 2010/03/24
CRDT- 2009/09/26 06:00
PHST- 2009/04/26 00:00 [received]
PHST- 2009/06/30 00:00 [revised]
PHST- 2009/08/11 00:00 [accepted]
PHST- 2009/09/26 06:00 [entrez]
PHST- 2009/09/26 06:00 [pubmed]
PHST- 2009/10/10 06:00 [medline]
PHST- 2010/03/24 00:00 [pmc-release]
AID - S0896-6273(09)00616-3 [pii]
AID - 10.1016/j.neuron.2009.08.006 [doi]
PST - ppublish
SO  - Neuron. 2009 Sep 24;63(6):788-802. doi: 10.1016/j.neuron.2009.08.006.