PMID- 19786569
OWN - NLM
STAT- MEDLINE
DCOM- 20091211
LR  - 20211203
IS  - 1098-5549 (Electronic)
IS  - 0270-7306 (Print)
IS  - 0270-7306 (Linking)
VI  - 29
IP  - 23
DP  - 2009 Dec
TI  - Crucial role for Mst1 and Mst2 kinases in early embryonic development of the 
      mouse.
PG  - 6309-20
LID - 10.1128/MCB.00551-09 [doi]
AB  - Mammalian sterile 20-like kinases 1 and 2 (Mst1 and Mst2, respectively) are 
      potent serine/threonine kinases that are involved in cell proliferation and cell 
      death. To investigate the physiological functions of Mst1 and Mst2, we generated 
      Mst1 and Mst2 mutant mice. Mst1(-/-) and Mst2(-/-) mice were viable and fertile 
      and developed normally, suggesting possible functional overlaps between the two 
      genes. A characterization of heterozygous and homozygous combinations of Mst1 and 
      Mst2 mutant mice showed that mice containing a single copy of either gene 
      underwent normal organ development; however, Mst1(-/-); Mst2(-/-) mice lacking 
      both Mst1 and Mst2 genes started dying in utero at approximately embryonic day 
      8.5. Mst1(-/-); Mst2(-/-) mice exhibited severe growth retardation, failed 
      placental development, impaired yolk sac/embryo vascular patterning and primitive 
      hematopoiesis, increased apoptosis in placentas and embryos, and disorganized 
      proliferating cells in the embryo proper. These findings indicate that both Mst1 
      and Mst2 kinases play essential roles in early mouse development, regulating 
      placental development, vascular patterning, primitive hematopoiesis, and cell 
      proliferation and survival.
FAU - Oh, Sangphil
AU  - Oh S
AD  - National Research Laboratory of Molecular Genetics, Department of Biological 
      Science, KAIST, Daejeon 305-701, South Korea.
FAU - Lee, Dongjun
AU  - Lee D
FAU - Kim, Tackhoon
AU  - Kim T
FAU - Kim, Tae-Shin
AU  - Kim TS
FAU - Oh, Hyun Jung
AU  - Oh HJ
FAU - Hwang, Chae Young
AU  - Hwang CY
FAU - Kong, Young-Yun
AU  - Kong YY
FAU - Kwon, Ki-Sun
AU  - Kwon KS
FAU - Lim, Dae-Sik
AU  - Lim DS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090928
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - EC 2.7.1.- (Stk4 protein, mouse)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (Serine-Threonine Kinase 3)
RN  - EC 2.7.11.1 (Stk3 protein, mouse)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Cell Proliferation
MH  - Embryo, Mammalian/blood supply/cytology/*enzymology
MH  - *Embryonic Development
MH  - Female
MH  - Gene Expression Regulation, Developmental
MH  - Gene Expression Regulation, Enzymologic
MH  - Hematopoiesis
MH  - Mice
MH  - Mice, Knockout
MH  - Placenta/abnormalities/enzymology
MH  - Pregnancy
MH  - Protein Serine-Threonine Kinases/deficiency/genetics/*metabolism
MH  - Serine-Threonine Kinase 3
MH  - Signal Transduction
PMC - PMC2786698
EDAT- 2009/09/30 06:00
MHDA- 2009/12/16 06:00
PMCR- 2010/06/01
CRDT- 2009/09/30 06:00
PHST- 2009/09/30 06:00 [entrez]
PHST- 2009/09/30 06:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2010/06/01 00:00 [pmc-release]
AID - MCB.00551-09 [pii]
AID - 0551-09 [pii]
AID - 10.1128/MCB.00551-09 [doi]
PST - ppublish
SO  - Mol Cell Biol. 2009 Dec;29(23):6309-20. doi: 10.1128/MCB.00551-09. Epub 2009 Sep 
      28.