PMID- 19788052
OWN - NLM
STAT- MEDLINE
DCOM- 20091020
LR  - 20220408
IS  - 0722-5091 (Print)
IS  - 0722-5091 (Linking)
VI  - 28
IP  - 5
DP  - 2009 Sep-Oct
TI  - Clinical and immunohistochemical prognostic factors in adult glioblastoma 
      patients.
PG  - 362-72
AB  - OBJECTIVE: Glioblastomas are the commonest and the most malignant of all adult 
      brain tumors, characterized by genetic instability, intratumoral 
      histopathological variability, and unpredictable clinical behavior. The utility 
      of tumor markers that reflect their underlying biology is becoming increasingly 
      important with respect to patient prognostication and their potential role as 
      molecular targets of therapy is being recognized. In this study, we aimed to 
      identify the clinical factors and some immunohistochemical markers that could 
      have an effect on patient survival in supratentorial glioblastomas. MATERIALS AND 
      METHODS: We evaluated 54 cases of adult supratentorial glioblastomas operated 
      over a span of 1 year, with respect to clinical features such as age, Karnofsky 
      performance score (KPS), extent of resection, adjuvant therapy, and 
      immunohistochemical expression of p53, EGFR (Epidermal Growth Factor Receptor) 
      and PTEN (Phosphatase and Tensin homolog). RESULTS: Radiotherapy and KPS at 
      presentation were significant predictors of outcome in both univariate and 
      multivariate analyses. Among immunohistochemical variables; loss of PTEN 
      expression in association with over-expression of EGFR showed a trend towards 
      poorer survival, in univariate analysis. Over-expression of EGFR and/or p53 
      emerged as significant predictors of poor outcome on multivariate analysis, 
      despite failing to prognosticate on univariate analysis. CONCLUSIONS: Our study 
      shows that EGFR and p53 overexpression along with loss of PTEN expression are 
      important adjuncts to clinical variables in prognosticating glioblastoma 
      patients.
FAU - Umesh, S
AU  - Umesh S
AD  - Department of Neurosurgery, National Institute of Mental Health and 
      Neurosciences, Bangalore, Karnataka, India.
FAU - Tandon, A
AU  - Tandon A
FAU - Santosh, V
AU  - Santosh V
FAU - Anandh, B
AU  - Anandh B
FAU - Sampath, S
AU  - Sampath S
FAU - Chandramouli, B A
AU  - Chandramouli BA
FAU - Sastry Kolluri, V R
AU  - Sastry Kolluri VR
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Neuropathol
JT  - Clinical neuropathology
JID - 8214420
RN  - 0 (Tumor Suppressor Protein p53)
RN  - EC 2.7.10.1 (EGFR protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (PTEN protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - ErbB Receptors/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Glioblastoma/*diagnosis/metabolism/therapy
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - PTEN Phosphohydrolase/metabolism
MH  - Prognosis
MH  - Severity of Illness Index
MH  - Supratentorial Neoplasms/*diagnosis/metabolism/therapy
MH  - Treatment Outcome
MH  - Tumor Suppressor Protein p53/metabolism
MH  - Young Adult
EDAT- 2009/10/01 06:00
MHDA- 2009/10/21 06:00
CRDT- 2009/10/01 06:00
PHST- 2009/10/01 06:00 [entrez]
PHST- 2009/10/01 06:00 [pubmed]
PHST- 2009/10/21 06:00 [medline]
AID - 6584 [pii]
PST - ppublish
SO  - Clin Neuropathol. 2009 Sep-Oct;28(5):362-72.