PMID- 19788585
OWN - NLM
STAT- MEDLINE
DCOM- 20091203
LR  - 20231011
IS  - 1365-2184 (Electronic)
IS  - 0960-7722 (Print)
IS  - 0960-7722 (Linking)
VI  - 42
IP  - 6
DP  - 2009 Dec
TI  - The stem cells of small intestinal crypts: where are they?
PG  - 731-50
LID - 10.1111/j.1365-2184.2009.00642.x [doi]
AB  - Recently, there has been resurgence of interest in the question of small 
      intestinal stem cells, their precise location and numbers in the crypts. In this 
      article, we attempt to re-assess the data, including historical information often 
      omitted in recent studies on the subject. The conclusion we draw is that the 
      evidence supports the concept that active murine small intestinal stem cells in 
      steady state are few in number and are proliferative. There are two evolving, but 
      divergent views on their location (which may be more related to scope of 
      capability and reversibility than to location) several lineage labelling and stem 
      cell self-renewing studies (based on Lgr5 expression) suggest a location 
      intercalated between the Paneth cells (crypt base columnar cells (CBCCs)), or 
      classical cell kinetic, label-retention and radiobiological evidence plus other 
      recent studies, pointing to a location four cell positions luminally from the 
      base of the crypt The latter is supported by recent lineage labelling of 
      Bmi-1-expressing cells and by studies on expression of Wip-1 phosphatase. The 
      situation in the human small intestine remains unclear, but recent mtDNA mutation 
      studies suggest that the stem cells in humans are also located above the Paneth 
      cell zone. There could be a distinct and as yet undiscovered relationship between 
      these observed traits, with stem cell properties both in cells of the crypt base 
      and those at cell position 4.
FAU - Potten, C S
AU  - Potten CS
AD  - Epistem Ltd, Manchester, UK. c.potten@epistem.co.uk
FAU - Gandara, R
AU  - Gandara R
FAU - Mahida, Y R
AU  - Mahida YR
FAU - Loeffler, M
AU  - Loeffler M
FAU - Wright, N A
AU  - Wright NA
LA  - eng
GR  - G0100577/MRC_/Medical Research Council/United Kingdom
GR  - G0500067/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20090928
PL  - England
TA  - Cell Prolif
JT  - Cell proliferation
JID - 9105195
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Cell Differentiation
MH  - Humans
MH  - Immunohistochemistry
MH  - Intestine, Small/*cytology
MH  - Mice
MH  - Stem Cells/*cytology
PMC - PMC6496740
EDAT- 2009/10/01 06:00
MHDA- 2009/12/16 06:00
PMCR- 2009/09/28
CRDT- 2009/10/01 06:00
PHST- 2009/10/01 06:00 [entrez]
PHST- 2009/10/01 06:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2009/09/28 00:00 [pmc-release]
AID - CPR642 [pii]
AID - 10.1111/j.1365-2184.2009.00642.x [doi]
PST - ppublish
SO  - Cell Prolif. 2009 Dec;42(6):731-50. doi: 10.1111/j.1365-2184.2009.00642.x. Epub 
      2009 Sep 28.