PMID- 19794444
OWN - NLM
STAT- MEDLINE
DCOM- 20091012
LR  - 20220331
IS  - 1474-1784 (Electronic)
IS  - 1474-1776 (Linking)
VI  - 8
IP  - 10
DP  - 2009 Oct
TI  - Tumour-initiating cells: challenges and opportunities for anticancer drug 
      discovery.
PG  - 806-23
LID - 10.1038/nrd2137 [doi]
AB  - The hypothesis that cancer is driven by tumour-initiating cells (popularly known 
      as cancer stem cells) has recently attracted a great deal of attention, owing to 
      the promise of a novel cellular target for the treatment of haematopoietic and 
      solid malignancies. Furthermore, it seems that tumour-initiating cells might be 
      resistant to many conventional cancer therapies, which might explain the 
      limitations of these agents in curing human malignancies. Although much work is 
      still needed to identify and characterize tumour-initiating cells, efforts are 
      now being directed towards identifying therapeutic strategies that could target 
      these cells. This Review considers recent advances in the cancer stem cell field, 
      focusing on the challenges and opportunities for anticancer drug discovery.
FAU - Zhou, Bin-Bing S
AU  - Zhou BB
AD  - Oncology Discovery, Wyeth Research, 401 North Middletown Road, Pearl River, New 
      York 10965, USA. zhoub@wyeth.com
FAU - Zhang, Haiying
AU  - Zhang H
FAU - Damelin, Marc
AU  - Damelin M
FAU - Geles, Kenneth G
AU  - Geles KG
FAU - Grindley, Justin C
AU  - Grindley JC
FAU - Dirks, Peter B
AU  - Dirks PB
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nat Rev Drug Discov
JT  - Nature reviews. Drug discovery
JID - 101124171
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology/*therapeutic use
MH  - Cell Line, Tumor
MH  - Drug Discovery/methods/*trends
MH  - Humans
MH  - Neoplasms/*drug therapy/*pathology
MH  - Neoplastic Stem Cells/drug effects/pathology
RF  - 205
EDAT- 2009/10/02 06:00
MHDA- 2009/10/13 06:00
CRDT- 2009/10/02 06:00
PHST- 2009/10/02 06:00 [entrez]
PHST- 2009/10/02 06:00 [pubmed]
PHST- 2009/10/13 06:00 [medline]
AID - nrd2137 [pii]
AID - 10.1038/nrd2137 [doi]
PST - ppublish
SO  - Nat Rev Drug Discov. 2009 Oct;8(10):806-23. doi: 10.1038/nrd2137.