PMID- 19796244
OWN - NLM
STAT- MEDLINE
DCOM- 20091023
LR  - 20230208
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1176
DP  - 2009 Sep
TI  - Antitumor immunity and cancer stem cells.
PG  - 154-69
LID - 10.1111/j.1749-6632.2009.04568.x [doi]
AB  - Self-renewing cancer stem cells (CSC) capable of spawning more differentiated 
      tumor cell progeny are required for tumorigenesis and neoplastic progression of 
      leukemias and several solid cancers. The mechanisms by which CSC cause tumor 
      initiation and growth are currently unknown. Recent findings that suggest a 
      negative correlation between degrees of host immunocompetence and rates of cancer 
      development raise the possibility that only a restricted minority of malignant 
      cells, namely CSC, may possess the phenotypic and functional characteristics to 
      evade host antitumor immunity. In human malignant melanoma, a highly immunogenic 
      cancer, we recently identified malignant melanoma initiating cells (MMIC), a 
      novel type of CSC, based on selective expression of the chemoresistance mediator 
      ABCB5. Here we present evidence of a relative immune privilege of ABCB5(+) MMIC, 
      suggesting refractoriness to current immunotherapeutic treatment strategies. We 
      discuss our findings in the context of established immunomodulatory functions of 
      physiologic stem cells and in relation to mechanisms responsible for the 
      downregulation of immune responses against tumors. We propose that the MMIC 
      subset might be responsible for melanoma immune evasion and that immunomodulation 
      might represent one mechanism by which CSC advance tumorigenic growth and 
      resistance to immunotherapy. Accordingly, the possibility of an MMIC-driven tumor 
      escape from immune-mediated rejection has important implications for current 
      melanoma immunotherapy.
FAU - Schatton, Tobias
AU  - Schatton T
AD  - Transplantation Research Center, Children's Hospital Boston, Harvard Medical 
      School, Boston, Massachusetts 02115, USA.
FAU - Frank, Markus H
AU  - Frank MH
LA  - eng
GR  - R01 CA113796-03/CA/NCI NIH HHS/United States
GR  - R01 CA138231-02/CA/NCI NIH HHS/United States
GR  - P50 CA093683/CA/NCI NIH HHS/United States
GR  - R01 CA113796-02/CA/NCI NIH HHS/United States
GR  - P50 CA093683-08/CA/NCI NIH HHS/United States
GR  - R01 CA138231-01/CA/NCI NIH HHS/United States
GR  - R01 CA138231/CA/NCI NIH HHS/United States
GR  - R01 CA113796-05/CA/NCI NIH HHS/United States
GR  - R01 CA113796-01A1/CA/NCI NIH HHS/United States
GR  - R01 CA113796-04/CA/NCI NIH HHS/United States
GR  - 1R01CA113796-01A1/CA/NCI NIH HHS/United States
GR  - P50 CA093683-07/CA/NCI NIH HHS/United States
GR  - R01 CA113796/CA/NCI NIH HHS/United States
GR  - 1R01CA138231-01/CA/NCI NIH HHS/United States
GR  - P50 CA093683-06A2/CA/NCI NIH HHS/United States
GR  - 2P50CA093683-05S2/CA/NCI NIH HHS/United States
GR  - R01 CA138231-03/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (ABCB5 protein, human)
RN  - 0 (ABCB5 protein, mouse)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 1)
RN  - 0 (ATP-Binding Cassette Transporters)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 1/biosynthesis
MH  - ATP-Binding Cassette Transporters/biosynthesis
MH  - Animals
MH  - Disease Models, Animal
MH  - Humans
MH  - *Immunologic Surveillance
MH  - Immunotherapy
MH  - Melanoma/*immunology/*therapy
MH  - Mice
MH  - Neoplastic Stem Cells/*immunology
MH  - *Tumor Escape
PMC - PMC2893543
MID - NIHMS209144
COIS- Conflicts of Interest The authors declare no conflicts of interest.
EDAT- 2009/10/03 06:00
MHDA- 2009/10/24 06:00
PMCR- 2010/06/29
CRDT- 2009/10/03 06:00
PHST- 2009/10/03 06:00 [entrez]
PHST- 2009/10/03 06:00 [pubmed]
PHST- 2009/10/24 06:00 [medline]
PHST- 2010/06/29 00:00 [pmc-release]
AID - NYAS4568 [pii]
AID - 10.1111/j.1749-6632.2009.04568.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2009 Sep;1176:154-69. doi: 10.1111/j.1749-6632.2009.04568.x.