PMID- 19829296
OWN - NLM
STAT- MEDLINE
DCOM- 20091223
LR  - 20230207
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 462
IP  - 7269
DP  - 2009 Nov 5
TI  - Effector T cell interactions with meningeal vascular structures in nascent 
      autoimmune CNS lesions.
PG  - 94-8
LID - 10.1038/nature08478 [doi]
AB  - The tissues of the central nervous system are effectively shielded from the blood 
      circulation by specialized vessels that are impermeable not only to cells, but 
      also to most macromolecules circulating in the blood. Despite this seemingly 
      absolute seclusion, central nervous system tissues are subject to immune 
      surveillance and are vulnerable to autoimmune attacks. Using intravital 
      two-photon imaging in a Lewis rat model of experimental autoimmune 
      encephalomyelitis, here we present in real-time the interactive processes between 
      effector T cells and cerebral structures from their first arrival to manifest 
      autoimmune disease. We observed that incoming effector T cells successively 
      scanned three planes. The T cells got arrested to leptomeningeal vessels and 
      immediately monitored the luminal surface, crawling preferentially against the 
      blood flow. After diapedesis, the cells continued their scan on the abluminal 
      vascular surface and the underlying leptomeningeal (pial) membrane. There, the T 
      cells encountered phagocytes that effectively present antigens, foreign as well 
      as myelin proteins. These contacts stimulated the effector T cells to produce 
      pro-inflammatory mediators, and provided a trigger to tissue invasion and the 
      formation of inflammatory infiltrations.
FAU - Bartholomaus, Ingo
AU  - Bartholomaus I
AD  - Max Planck Institute for Neurobiology, 82152 Martinsried, Germany.
FAU - Kawakami, Naoto
AU  - Kawakami N
FAU - Odoardi, Francesca
AU  - Odoardi F
FAU - Schlager, Christian
AU  - Schlager C
FAU - Miljkovic, Djordje
AU  - Miljkovic D
FAU - Ellwart, Joachim W
AU  - Ellwart JW
FAU - Klinkert, Wolfgang E F
AU  - Klinkert WE
FAU - Flugel-Koch, Cassandra
AU  - Flugel-Koch C
FAU - Issekutz, Thomas B
AU  - Issekutz TB
FAU - Wekerle, Hartmut
AU  - Wekerle H
FAU - Flugel, Alexander
AU  - Flugel A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091014
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Antigens)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
CIN - Nature. 2009 Nov 5;462(7269):41-2. PMID: 19890316
MH  - Animals
MH  - Antigen-Presenting Cells/immunology
MH  - Antigens/immunology
MH  - Cell Movement
MH  - Cells, Cultured
MH  - Central Nervous System Diseases/*immunology/*pathology
MH  - Encephalomyelitis, Autoimmune, Experimental/*immunology/*pathology
MH  - Meninges/*blood supply/*immunology/pathology
MH  - Mice
MH  - Ovalbumin/immunology
MH  - Phagocytes/immunology
MH  - Rats
MH  - Rats, Inbred Lew
MH  - T-Lymphocytes/*immunology
EDAT- 2009/10/16 06:00
MHDA- 2009/12/24 06:00
CRDT- 2009/10/16 06:00
PHST- 2009/07/06 00:00 [received]
PHST- 2009/09/01 00:00 [accepted]
PHST- 2009/10/16 06:00 [entrez]
PHST- 2009/10/16 06:00 [pubmed]
PHST- 2009/12/24 06:00 [medline]
AID - nature08478 [pii]
AID - 10.1038/nature08478 [doi]
PST - ppublish
SO  - Nature. 2009 Nov 5;462(7269):94-8. doi: 10.1038/nature08478. Epub 2009 Oct 14.