PMID- 19837039
OWN - NLM
STAT- MEDLINE
DCOM- 20091113
LR  - 20211020
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 139
IP  - 2
DP  - 2009 Oct 16
TI  - Writing memories with light-addressable reinforcement circuitry.
PG  - 405-15
LID - 10.1016/j.cell.2009.08.034 [doi]
AB  - Dopaminergic neurons are thought to drive learning by signaling changes in the 
      expectations of salient events, such as rewards or punishments. Olfactory 
      conditioning in Drosophila requires direct dopamine action on intrinsic mushroom 
      body neurons, the likely storage sites of olfactory memories. Neither the 
      cellular sources of the conditioning dopamine nor its precise postsynaptic 
      targets are known. By optically controlling genetically circumscribed subsets of 
      dopaminergic neurons in the behaving fly, we have mapped the origin of aversive 
      reinforcement signals to the PPL1 cluster of 12 dopaminergic cells. PPL1 
      projections target restricted domains in the vertical lobes and heel of the 
      mushroom body. Artificially evoked activity in a small number of identifiable 
      cells thus suffices for programming behaviorally meaningful memories. The 
      delineation of core reinforcement circuitry is an essential first step in 
      dissecting the neural mechanisms that compute and represent valuations, store 
      associations, and guide actions.
FAU - Claridge-Chang, Adam
AU  - Claridge-Chang A
AD  - Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, 
      Oxford OX1 3PT, UK.
FAU - Roorda, Robert D
AU  - Roorda RD
FAU - Vrontou, Eleftheria
AU  - Vrontou E
FAU - Sjulson, Lucas
AU  - Sjulson L
FAU - Li, Haiyan
AU  - Li H
FAU - Hirsh, Jay
AU  - Hirsh J
FAU - Miesenbock, Gero
AU  - Miesenbock G
LA  - eng
GR  - G0700888/MRC_/Medical Research Council/United Kingdom
GR  - G0701225/MRC_/Medical Research Council/United Kingdom
GR  - R01 DA017297/DA/NIDA NIH HHS/United States
GR  - R01 DA030601/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
EIN - Cell. 2009 Nov 25;139(5):1022
CIN - Cell. 2009 Oct 16;139(2):225-7. PMID: 19837025
MH  - Animals
MH  - Behavior, Animal
MH  - Brain/physiology
MH  - Conditioning, Classical
MH  - Dopamine/metabolism/physiology
MH  - Drosophila melanogaster/*physiology
MH  - Electric Stimulation
MH  - Memory
MH  - Mushroom Bodies/innervation/physiology
MH  - Neurons/physiology
MH  - Olfactory Pathways
PMC - PMC3920284
MID - NIHMS144154
EDAT- 2009/10/20 06:00
MHDA- 2009/11/17 06:00
PMCR- 2014/02/11
CRDT- 2009/10/20 06:00
PHST- 2009/04/06 00:00 [received]
PHST- 2009/05/25 00:00 [revised]
PHST- 2009/08/17 00:00 [accepted]
PHST- 2009/10/20 06:00 [entrez]
PHST- 2009/10/20 06:00 [pubmed]
PHST- 2009/11/17 06:00 [medline]
PHST- 2014/02/11 00:00 [pmc-release]
AID - S0092-8674(09)01104-0 [pii]
AID - 10.1016/j.cell.2009.08.034 [doi]
PST - ppublish
SO  - Cell. 2009 Oct 16;139(2):405-15. doi: 10.1016/j.cell.2009.08.034.