PMID- 19844908 OWN - NLM STAT- MEDLINE DCOM- 20100310 LR - 20220410 IS - 1613-6829 (Electronic) IS - 1613-6810 (Linking) VI - 6 IP - 1 DP - 2010 Jan TI - Effect of surface properties on nanoparticle-cell interactions. PG - 12-21 LID - 10.1002/smll.200901158 [doi] AB - The interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed. FAU - Verma, Ayush AU - Verma A AD - Department of Materials Science and Engineering, Massachusetts Institute of Technology (MIT), 77 Massachusetts Avenue, Cambridge, MA 02139, USA. FAU - Stellacci, Francesco AU - Stellacci F LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - Germany TA - Small JT - Small (Weinheim an der Bergstrasse, Germany) JID - 101235338 RN - 0 (Biocompatible Materials) SB - IM MH - Biocompatible Materials/*chemistry MH - *Cell Physiological Phenomena MH - Cells, Cultured/*chemistry MH - Materials Testing MH - Nanostructures/*chemistry/*ultrastructure MH - Nanotechnology/*methods MH - Particle Size MH - *Surface Properties RF - 82 EDAT- 2009/10/22 06:00 MHDA- 2010/03/11 06:00 CRDT- 2009/10/22 06:00 PHST- 2009/10/22 06:00 [entrez] PHST- 2009/10/22 06:00 [pubmed] PHST- 2010/03/11 06:00 [medline] AID - 10.1002/smll.200901158 [doi] PST - ppublish SO - Small. 2010 Jan;6(1):12-21. doi: 10.1002/smll.200901158.