PMID- 19851315
OWN - NLM
STAT- MEDLINE
DCOM- 20091109
LR  - 20240109
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Print)
IS  - 1474-175X (Linking)
VI  - 9
IP  - 11
DP  - 2009 Nov
TI  - STATs in cancer inflammation and immunity: a leading role for STAT3.
PG  - 798-809
LID - 10.1038/nrc2734 [doi]
AB  - Commensurate with their roles in regulating cytokine-dependent inflammation and 
      immunity, signal transducer and activator of transcription (STAT) proteins are 
      central in determining whether immune responses in the tumour microenvironment 
      promote or inhibit cancer. Persistently activated STAT3 and, to some extent, 
      STAT5 increase tumour cell proliferation, survival and invasion while suppressing 
      anti-tumour immunity. The persistent activation of STAT3 also mediates 
      tumour-promoting inflammation. STAT3 has this dual role in tumour inflammation 
      and immunity by promoting pro-oncogenic inflammatory pathways, including nuclear 
      factor-kappaB (NF-kappaB) and interleukin-6 (IL-6)-GP130-Janus kinase (JAK) 
      pathways, and by opposing STAT1- and NF-kappaB-mediated T helper 1 anti-tumour 
      immune responses. Consequently, STAT3 is a promising target to redirect 
      inflammation for cancer therapy.
FAU - Yu, Hua
AU  - Yu H
AD  - Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, 
      California 91010, USA. hyu@coh.org
FAU - Pardoll, Drew
AU  - Pardoll D
FAU - Jove, Richard
AU  - Jove R
LA  - eng
GR  - P30 CA006973/CA/NCI NIH HHS/United States
GR  - P30 CA021765/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
RN  - 0 (STAT Transcription Factors)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT5 Transcription Factor)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Immunity
MH  - Neoplasms/genetics/*immunology
MH  - STAT Transcription Factors/genetics/*immunology
MH  - STAT3 Transcription Factor/genetics/*immunology
MH  - STAT5 Transcription Factor/genetics/immunology
MH  - Signal Transduction
PMC - PMC4856025
MID - NIHMS779912
EDAT- 2009/10/24 06:00
MHDA- 2009/11/10 06:00
PMCR- 2016/05/04
CRDT- 2009/10/24 06:00
PHST- 2009/10/24 06:00 [entrez]
PHST- 2009/10/24 06:00 [pubmed]
PHST- 2009/11/10 06:00 [medline]
PHST- 2016/05/04 00:00 [pmc-release]
AID - nrc2734 [pii]
AID - 10.1038/nrc2734 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2009 Nov;9(11):798-809. doi: 10.1038/nrc2734.