PMID- 19851336
OWN - NLM
STAT- MEDLINE
DCOM- 20091106
LR  - 20220409
IS  - 1471-0080 (Electronic)
IS  - 1471-0072 (Print)
IS  - 1471-0072 (Linking)
VI  - 10
IP  - 11
DP  - 2009 Nov
TI  - Non-muscle myosin II takes centre stage in cell adhesion and migration.
PG  - 778-90
LID - 10.1038/nrm2786 [doi]
AB  - Non-muscle myosin II (NM II) is an actin-binding protein that has actin 
      cross-linking and contractile properties and is regulated by the phosphorylation 
      of its light and heavy chains. The three mammalian NM II isoforms have both 
      overlapping and unique properties. Owing to its position downstream of convergent 
      signalling pathways, NM II is central in the control of cell adhesion, cell 
      migration and tissue architecture. Recent insight into the role of NM II in these 
      processes has been gained from loss-of-function and mutant approaches, methods 
      that quantitatively measure actin and adhesion dynamics and the discovery of NM 
      II mutations that cause monogenic diseases.
FAU - Vicente-Manzanares, Miguel
AU  - Vicente-Manzanares M
AD  - Department of Cell Biology, University of Virginia School of Medicine, 
      Charlottesville, Virginia 22908, USA. miguelvix@virginia.edu
FAU - Ma, Xuefei
AU  - Ma X
FAU - Adelstein, Robert S
AU  - Adelstein RS
FAU - Horwitz, Alan Rick
AU  - Horwitz AR
LA  - eng
GR  - R01 GM023244-34/GM/NIGMS NIH HHS/United States
GR  - U54 GM064346/GM/NIGMS NIH HHS/United States
GR  - GM23244/GM/NIGMS NIH HHS/United States
GR  - U54 GM064346-09/GM/NIGMS NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - R37 GM023244/GM/NIGMS NIH HHS/United States
GR  - U54-GM064346/GM/NIGMS NIH HHS/United States
GR  - R01 GM023244/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Review
PL  - England
TA  - Nat Rev Mol Cell Biol
JT  - Nature reviews. Molecular cell biology
JID - 100962782
RN  - EC 3.6.1.- (Myosin Type II)
SB  - IM
MH  - Animals
MH  - Cell Adhesion/*physiology
MH  - Cell Movement/*physiology
MH  - Humans
MH  - Myosin Type II/*metabolism
PMC - PMC2834236
MID - NIHMS178003
EDAT- 2009/10/24 06:00
MHDA- 2009/11/07 06:00
PMCR- 2010/03/08
CRDT- 2009/10/24 06:00
PHST- 2009/10/24 06:00 [entrez]
PHST- 2009/10/24 06:00 [pubmed]
PHST- 2009/11/07 06:00 [medline]
PHST- 2010/03/08 00:00 [pmc-release]
AID - nrm2786 [pii]
AID - 10.1038/nrm2786 [doi]
PST - ppublish
SO  - Nat Rev Mol Cell Biol. 2009 Nov;10(11):778-90. doi: 10.1038/nrm2786.