PMID- 19860656
OWN - NLM
STAT- MEDLINE
DCOM- 20100125
LR  - 20211020
IS  - 1875-5631 (Electronic)
IS  - 1566-5232 (Print)
IS  - 1566-5232 (Linking)
VI  - 9
IP  - 5
DP  - 2009 Oct
TI  - Oncolytic adenovirus: preclinical and clinical studies in patients with human 
      malignant gliomas.
PG  - 422-7
AB  - Oncolytic adenoviruses are emerging as a promising alternative therapy for glioma 
      patients and are currently being tested in clinic. In this review, we summarize 
      our experience with gene-based therapy targeting RB pathway in gliomas. Our study 
      has evolved from the development of RB-expressing adenoviral vectors to the 
      characterization of the oncolytic effects on gliomas of the replication competent 
      adenoviruses Delta-24, Delta-24-RGD and ICOVIR. We also review the successful 
      combination of the viruses with chemotherapies that are routinely used in glioma 
      patients, the efficacy of Delta-24-RGD against brain tumor stem cells, the newly 
      described adenovirus-induced autophagy and the potential for the systemic 
      delivery of the oncolytic viruses with human mesenchymal stem cells. Finally, we 
      comment on the preclinical and clinical studies of p53 expressing adenoviral 
      vector and the lessons learned from the experience of Onyx-015, the first 
      oncolytic adenovirus tested in clinical setting.
FAU - Jiang, Hong
AU  - Jiang H
AD  - Neuro-Oncology, The University of Texas M.D. Anderson Cancer Center, Texas, USA. 
      hjiang@mdanderson.org
FAU - Gomez-Manzano, Candelaria
AU  - Gomez-Manzano C
FAU - Lang, Frederick F
AU  - Lang FF
FAU - Alemany, Ramon
AU  - Alemany R
FAU - Fueyo, Juan
AU  - Fueyo J
LA  - eng
GR  - P50 CA127001/CA/NCI NIH HHS/United States
GR  - P50 CA127001-020001/CA/NCI NIH HHS/United States
GR  - P50 CA 127001/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United Arab Emirates
TA  - Curr Gene Ther
JT  - Current gene therapy
JID - 101125446
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adenoviridae/*genetics
MH  - Antineoplastic Agents/therapeutic use
MH  - Brain Neoplasms/drug therapy/*therapy
MH  - Genetic Vectors
MH  - Glioma/drug therapy/*therapy
MH  - Humans
MH  - *Oncolytic Virotherapy
PMC - PMC2935304
MID - NIHMS230697
EDAT- 2009/10/29 06:00
MHDA- 2010/01/26 06:00
PMCR- 2010/09/07
CRDT- 2009/10/29 06:00
PHST- 2009/10/29 06:00 [entrez]
PHST- 2009/10/29 06:00 [pubmed]
PHST- 2010/01/26 06:00 [medline]
PHST- 2010/09/07 00:00 [pmc-release]
AID - 10.2174/156652309789753356 [doi]
PST - ppublish
SO  - Curr Gene Ther. 2009 Oct;9(5):422-7. doi: 10.2174/156652309789753356.