PMID- 19870634
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100623
LR  - 20220318
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 65
IP  - 6
DP  - 1937 May 31
TI  - THE USE OF YELLOW FEVER VIRUS MODIFIED BY IN VITRO CULTIVATION FOR HUMAN 
      IMMUNIZATION.
PG  - 787-800
AB  - The response of rhesus monkeys to a subcutaneous inoculation with varying amounts 
      of virus modified by prolonged cultivation in vitro has been studied. The tissue 
      components of the medium consisted of chick embryo tissue containing minimal 
      amounts of nervous tissue. The immunity produced in monkeys, as measured by the 
      antibody titer developed, has no relation to the amount of virus inoculated. 
      Monkeys inoculated subcutaneously with the tissue culture virus are rendered 
      immune to a subsequent injection of a highly virulent yellow fever virus. This 
      resistance is already present 7 days after vaccination. The subcutaneous 
      inoculation of the culture virus into immune persons leads to a substantial 
      increase of the serum antibody titer. The results of vaccinating eight normal 
      persons with culture virus are presented. The reactions were minimal. The highest 
      temperature recorded following vaccination was 37.4 degrees C. The sera taken 
      from the eight vaccinated persons 2 to 4 weeks after inoculation with the tissue 
      culture virus showed the presence of yellow fever antibodies.
FAU - Theiler, M
AU  - Theiler M
AD  - Laboratories of the International Health Division, The Rockefeller Foundation, 
      New York.
FAU - Smith, H H
AU  - Smith HH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
PMC - PMC2133527
EDAT- 1937/05/31 00:00
MHDA- 1937/05/31 00:01
PMCR- 1937/11/30
CRDT- 2009/10/30 06:00
PHST- 2009/10/30 06:00 [entrez]
PHST- 1937/05/31 00:00 [pubmed]
PHST- 1937/05/31 00:01 [medline]
PHST- 1937/11/30 00:00 [pmc-release]
AID - 10.1084/jem.65.6.787 [doi]
PST - ppublish
SO  - J Exp Med. 1937 May 31;65(6):787-800. doi: 10.1084/jem.65.6.787.