PMID- 19879142
OWN - NLM
STAT- MEDLINE
DCOM- 20100301
LR  - 20151119
IS  - 1879-0445 (Electronic)
IS  - 0960-9822 (Linking)
VI  - 19
IP  - 22
DP  - 2009 Dec 1
TI  - Increased cell bond tension governs cell sorting at the Drosophila 
      anteroposterior compartment boundary.
PG  - 1950-5
LID - 10.1016/j.cub.2009.10.021 [doi]
AB  - Subdividing proliferating tissues into compartments is an evolutionarily 
      conserved strategy of animal development [1-6]. Signals across boundaries between 
      compartments can result in local expression of secreted proteins organizing 
      growth and patterning of tissues [1-6]. Sharp and straight interfaces between 
      compartments are crucial for stabilizing the position of such organizers and 
      therefore for precise implementation of body plans. Maintaining boundaries in 
      proliferating tissues requires mechanisms to counteract cell rearrangements 
      caused by cell division; however, the nature of such mechanisms remains unclear. 
      Here we quantitatively analyzed cell morphology and the response to the laser 
      ablation of cell bonds in the vicinity of the anteroposterior compartment 
      boundary in developing Drosophila wings. We found that mechanical tension is 
      approximately 2.5-fold increased on cell bonds along this compartment boundary as 
      compared to the remaining tissue. Cell bond tension is decreased in the presence 
      of Y-27632 [7], an inhibitor of Rho-kinase whose main effector is Myosin II [8]. 
      Simulations using a vertex model [9] demonstrate that a 2.5-fold increase in 
      local cell bond tension suffices to guide the rearrangement of cells after cell 
      division to maintain compartment boundaries. Our results provide a physical 
      mechanism in which the local increase in Myosin II-dependent cell bond tension 
      directs cell sorting at compartment boundaries.
FAU - Landsberg, Katharina P
AU  - Landsberg KP
AD  - Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
FAU - Farhadifar, Reza
AU  - Farhadifar R
FAU - Ranft, Jonas
AU  - Ranft J
FAU - Umetsu, Daiki
AU  - Umetsu D
FAU - Widmann, Thomas J
AU  - Widmann TJ
FAU - Bittig, Thomas
AU  - Bittig T
FAU - Said, Amani
AU  - Said A
FAU - Julicher, Frank
AU  - Julicher F
FAU - Dahmann, Christian
AU  - Dahmann C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091029
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
SB  - IM
CIN - Curr Biol. 2009 Dec 1;19(22):R1028-30. PMID: 19948137
MH  - Animals
MH  - *Body Patterning
MH  - Drosophila/*cytology/embryology
MH  - Wings, Animal/cytology/embryology
EDAT- 2009/11/03 06:00
MHDA- 2010/03/02 06:00
CRDT- 2009/11/03 06:00
PHST- 2009/03/18 00:00 [received]
PHST- 2009/10/01 00:00 [revised]
PHST- 2009/10/02 00:00 [accepted]
PHST- 2009/11/03 06:00 [entrez]
PHST- 2009/11/03 06:00 [pubmed]
PHST- 2010/03/02 06:00 [medline]
AID - S0960-9822(09)01840-5 [pii]
AID - 10.1016/j.cub.2009.10.021 [doi]
PST - ppublish
SO  - Curr Biol. 2009 Dec 1;19(22):1950-5. doi: 10.1016/j.cub.2009.10.021. Epub 2009 
      Oct 29.