PMID- 19896530
OWN - NLM
STAT- MEDLINE
DCOM- 20100922
LR  - 20240405
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Print)
IS  - 0889-1591 (Linking)
VI  - 24
IP  - 4
DP  - 2010 May
TI  - The immunoregulatory role of dopamine: an update.
PG  - 525-8
LID - 10.1016/j.bbi.2009.10.015 [doi]
AB  - The neurotransmitter dopamine (DA) is an important molecule bridging the nervous 
      and immune systems. DA through autocrine/paracrine manner modulates the functions 
      of immune effector cells by acting through its receptors present in these cells. 
      DA also has unique and opposite effects on T cell functions. Although DA 
      activates naive or resting T cells, but it inhibits activated T cells. In 
      addition, changes in the expression of DA receptors and their signaling pathways 
      especially in T cells are associated with altered immune functions in disorders 
      like schizophrenia and Parkinson's disease. These results suggest an 
      immunoregulatory role of DA. Therefore, targeting DA receptors and their 
      signaling pathways in these cells by using DA receptor agonists and antagonists 
      may be useful for the treatment of diseases where DA induced altered immunity 
      play a pathogenic role.
CI  - Copyright 2009 Elsevier Inc. All rights reserved.
FAU - Sarkar, Chandrani
AU  - Sarkar C
AD  - Department of Pathology, Ohio State University, Columbus, OH 43210, USA.
FAU - Basu, Biswarup
AU  - Basu B
FAU - Chakroborty, Debanjan
AU  - Chakroborty D
FAU - Dasgupta, Partha Sarthi
AU  - Dasgupta PS
FAU - Basu, Sujit
AU  - Basu S
LA  - eng
GR  - R01 CA124763-04/CA/NCI NIH HHS/United States
GR  - R01 CA124763/CA/NCI NIH HHS/United States
GR  - R21 CA118265-02/CA/NCI NIH HHS/United States
GR  - R21 CA118265/CA/NCI NIH HHS/United States
GR  - CA124763/CA/NCI NIH HHS/United States
GR  - CA118265/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20091105
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Dopamine Agonists)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Receptors, Dopamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Dopamine/*immunology/metabolism
MH  - Dopamine Agonists/pharmacology
MH  - Dopamine Antagonists/pharmacology
MH  - Humans
MH  - Parkinson Disease/drug therapy/immunology
MH  - Psychoneuroimmunology
MH  - Receptors, Dopamine/*immunology
MH  - Schizophrenia/drug therapy/immunology
MH  - Signal Transduction/drug effects/*immunology
MH  - T-Lymphocytes/drug effects/*immunology
PMC - PMC2856781
MID - NIHMS157681
EDAT- 2009/11/10 06:00
MHDA- 2010/09/24 06:00
PMCR- 2011/05/01
CRDT- 2009/11/10 06:00
PHST- 2009/08/07 00:00 [received]
PHST- 2009/10/17 00:00 [revised]
PHST- 2009/10/27 00:00 [accepted]
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
PHST- 2011/05/01 00:00 [pmc-release]
AID - S0889-1591(09)00482-6 [pii]
AID - 10.1016/j.bbi.2009.10.015 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2010 May;24(4):525-8. doi: 10.1016/j.bbi.2009.10.015. Epub 
      2009 Nov 5.