PMID- 19913529
OWN - NLM
STAT- MEDLINE
DCOM- 20100225
LR  - 20211203
IS  - 1095-564X (Electronic)
IS  - 0012-1606 (Linking)
VI  - 337
IP  - 2
DP  - 2010 Jan 15
TI  - Mob as tumor suppressor is activated at the cell membrane to control tissue 
      growth and organ size in Drosophila.
PG  - 274-83
LID - 10.1016/j.ydbio.2009.10.042 [doi]
AB  - Growth inhibition mediated by Hippo (Hpo) signaling is essential for tissue 
      growth and organ size control in Drosophila. However, the cellular mechanism by 
      which the core components like Mob as tumor suppressor (Mats) and Warts (Wts) 
      protein kinase are activated is poorly understood. In this work, we found that 
      the endogenous Mats is located at the plasma membrane in developing tissues. 
      Membrane targeting constitutively activates Mats to promote apoptosis and reduce 
      cell proliferation, which leads to reduced tissue growth and organ size. 
      Moreover, the ability of membrane-targeted Mats to inhibit tissue growth required 
      the wts gene activity and Wts kinase activity was increased by the activated Mats 
      in developing tissues. Consistent with the idea that Mats is a key component of 
      the Hpo pathway, Mats is required and sufficient to regulate Yki nuclear 
      localization. These results support a model in which the plasma membrane is an 
      important site of action for Mats tumor suppressor to control tissue growth and 
      organ size.
CI  - Copyright 2009 Elsevier Inc. All rights reserved.
FAU - Ho, Li-Lun
AU  - Ho LL
AD  - Intercollege Graduate Degree Program in Cell and Developmental Biology, The 
      Pennsylvania State University, University Park, PA 16802, USA.
FAU - Wei, Xiaomu
AU  - Wei X
FAU - Shimizu, Takeshi
AU  - Shimizu T
FAU - Lai, Zhi-Chun
AU  - Lai ZC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091112
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (Drosophila Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Mats protein, Drosophila)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.- (wts protein, Drosophila)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (hpo protein, Drosophila)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Cell Membrane/*metabolism
MH  - Cell Nucleus/metabolism
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Drosophila Proteins/*metabolism
MH  - Drosophila melanogaster/*cytology/enzymology/*growth & development/ultrastructure
MH  - Enzyme Activation
MH  - Epistasis, Genetic
MH  - Eye/cytology/ultrastructure
MH  - Intracellular Signaling Peptides and Proteins/metabolism
MH  - Organ Size
MH  - Organ Specificity
MH  - Protein Binding
MH  - Protein Kinases/metabolism
MH  - Protein Serine-Threonine Kinases/metabolism
MH  - Protein Transport
MH  - Subcellular Fractions/metabolism
MH  - Tumor Suppressor Proteins/*metabolism
EDAT- 2009/11/17 06:00
MHDA- 2010/02/26 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/09/03 00:00 [received]
PHST- 2009/10/29 00:00 [revised]
PHST- 2009/10/29 00:00 [accepted]
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/02/26 06:00 [medline]
AID - S0012-1606(09)01334-7 [pii]
AID - 10.1016/j.ydbio.2009.10.042 [doi]
PST - ppublish
SO  - Dev Biol. 2010 Jan 15;337(2):274-83. doi: 10.1016/j.ydbio.2009.10.042. Epub 2009 
      Nov 12.