PMID- 19922871
OWN - NLM
STAT- MEDLINE
DCOM- 20091214
LR  - 20240109
IS  - 1878-1551 (Electronic)
IS  - 1534-5807 (Print)
IS  - 1534-5807 (Linking)
VI  - 17
IP  - 5
DP  - 2009 Nov
TI  - A family of microRNAs encoded by myosin genes governs myosin expression and 
      muscle performance.
PG  - 662-73
LID - 10.1016/j.devcel.2009.10.013 [doi]
AB  - Myosin is the primary regulator of muscle strength and contractility. Here we 
      show that three myosin genes, Myh6, Myh7, and Myh7b, encode related intronic 
      microRNAs (miRNAs), which, in turn, control muscle myosin content, myofiber 
      identity, and muscle performance. Within the adult heart, the Myh6 gene, encoding 
      a fast myosin, coexpresses miR-208a, which regulates the expression of two slow 
      myosins and their intronic miRNAs, Myh7/miR-208b and Myh7b/miR-499, respectively. 
      miR-208b and miR-499 play redundant roles in the specification of muscle fiber 
      identity by activating slow and repressing fast myofiber gene programs. The 
      actions of these miRNAs are mediated in part by a collection of transcriptional 
      repressors of slow myofiber genes. These findings reveal that myosin genes not 
      only encode the major contractile proteins of muscle, but act more broadly to 
      influence muscle function by encoding a network of intronic miRNAs that control 
      muscle gene expression and performance.
FAU - van Rooij, Eva
AU  - van Rooij E
AD  - Department of Molecular Biology, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390-9148, USA.
FAU - Quiat, Daniel
AU  - Quiat D
FAU - Johnson, Brett A
AU  - Johnson BA
FAU - Sutherland, Lillian B
AU  - Sutherland LB
FAU - Qi, Xiaoxia
AU  - Qi X
FAU - Richardson, James A
AU  - Richardson JA
FAU - Kelm, Robert J Jr
AU  - Kelm RJ Jr
FAU - Olson, Eric N
AU  - Olson EN
LA  - eng
GR  - F30 HL103013/HL/NHLBI NIH HHS/United States
GR  - R01 HL093039/HL/NHLBI NIH HHS/United States
GR  - R01 HL093039-01A1/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Cell
JT  - Developmental cell
JID - 101120028
RN  - 0 (MYH14 protein, human)
RN  - 0 (MYH6 protein, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Mirn208 microRNA, mouse)
RN  - 0 (Myh14 protein, mouse)
RN  - EC 3.6.1.- (Cardiac Myosins)
RN  - EC 3.6.1.- (Myosin Type II)
RN  - EC 3.6.4.1 (Myosin Heavy Chains)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cardiac Myosins/genetics/metabolism
MH  - Cell Line
MH  - Chlorocebus aethiops
MH  - *Gene Expression Regulation, Developmental
MH  - Mice
MH  - MicroRNAs/*genetics
MH  - Muscle, Skeletal/*metabolism
MH  - Myosin Heavy Chains/*genetics/metabolism
MH  - Myosin Type II/genetics/metabolism
PMC - PMC2796371
MID - NIHMS157407
EDAT- 2009/11/20 06:00
MHDA- 2009/12/16 06:00
PMCR- 2010/11/17
CRDT- 2009/11/20 06:00
PHST- 2009/07/31 00:00 [received]
PHST- 2009/10/23 00:00 [revised]
PHST- 2009/10/26 00:00 [accepted]
PHST- 2009/11/20 06:00 [entrez]
PHST- 2009/11/20 06:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2010/11/17 00:00 [pmc-release]
AID - S1534-5807(09)00435-3 [pii]
AID - 10.1016/j.devcel.2009.10.013 [doi]
PST - ppublish
SO  - Dev Cell. 2009 Nov;17(5):662-73. doi: 10.1016/j.devcel.2009.10.013.