PMID- 19931353
OWN - NLM
STAT- MEDLINE
DCOM- 20100323
LR  - 20240418
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1805
IP  - 1
DP  - 2010 Jan
TI  - Tumor heterogeneity: causes and consequences.
PG  - 105-17
LID - 10.1016/j.bbcan.2009.11.002 [doi]
AB  - With rare exceptions, spontaneous tumors originate from a single cell. Yet, at 
      the time of clinical diagnosis, the majority of human tumors display startling 
      heterogeneity in many morphological and physiological features, such as 
      expression of cell surface receptors, proliferative and angiogenic potential. To 
      a substantial extent, this heterogeneity might be attributed to morphological and 
      epigenetic plasticity, but there is also strong evidence for the co-existence of 
      genetically divergent tumor cell clones within tumors. In this perspective, we 
      summarize the sources of intra-tumor phenotypic heterogeneity with emphasis on 
      genetic heterogeneity. We review experimental evidence for the existence of both 
      intra-tumor clonal heterogeneity as well as frequent evolutionary divergence 
      between primary tumors and metastatic outgrowths. Furthermore, we discuss 
      potential biological and clinical implications of intra-tumor clonal 
      heterogeneity.
CI  - Copyright (c) 2009 Elsevier B.V. All rights reserved.
FAU - Marusyk, Andriy
AU  - Marusyk A
AD  - Department of Medical Oncology, Dana-Farber Cancer Institute, Department of 
      Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical 
      School, 44 Binney Street, Boston, MA 02115, USA.
FAU - Polyak, Kornelia
AU  - Polyak K
LA  - eng
GR  - P01 CA080111/CA/NCI NIH HHS/United States
GR  - P01 CA080111-118269/CA/NCI NIH HHS/United States
GR  - P01 CA 080111/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20091118
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
SB  - IM
MH  - *Genetic Heterogeneity
MH  - Humans
MH  - Neoplasms/*genetics/*pathology
PMC - PMC2814927
MID - NIHMS160602
EDAT- 2009/11/26 06:00
MHDA- 2010/03/24 06:00
PMCR- 2011/01/01
CRDT- 2009/11/26 06:00
PHST- 2009/08/25 00:00 [received]
PHST- 2009/11/05 00:00 [revised]
PHST- 2009/11/10 00:00 [accepted]
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/03/24 06:00 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - S0304-419X(09)00074-2 [pii]
AID - 10.1016/j.bbcan.2009.11.002 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2010 Jan;1805(1):105-17. doi: 10.1016/j.bbcan.2009.11.002. 
      Epub 2009 Nov 18.