PMID- 19946328
OWN - NLM
STAT- MEDLINE
DCOM- 20100302
LR  - 20240319
IS  - 1476-5594 (Electronic)
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 29
IP  - 5
DP  - 2010 Feb 4
TI  - Defining the role of hypoxia-inducible factor 1 in cancer biology and 
      therapeutics.
PG  - 625-34
LID - 10.1038/onc.2009.441 [doi]
AB  - Adaptation of cancer cells to their microenvironment is an important driving 
      force in the clonal selection that leads to invasive and metastatic disease. O2 
      concentrations are markedly reduced in many human cancers compared with normal 
      tissue, and a major mechanism mediating adaptive responses to reduced O2 
      availability (hypoxia) is the regulation of transcription by hypoxia-inducible 
      factor 1 (HIF-1). This review summarizes the current state of knowledge regarding 
      the molecular mechanisms by which HIF-1 contributes to cancer progression, 
      focusing on (1) clinical data associating increased HIF-1 levels with patient 
      mortality; (2) preclinical data linking HIF-1 activity with tumor growth; (3) 
      molecular data linking specific HIF-1 target gene products to critical aspects of 
      cancer biology and (4) pharmacological data showing anticancer effects of HIF-1 
      inhibitors in mouse models of human cancer.
FAU - Semenza, G L
AU  - Semenza GL
AD  - Vascular Program, Institute for Cell Engineering, The Johns Hopkins University 
      School of Medicine, Baltimore, MD 21205, USA. gsemenza@jhmi.edu
LA  - eng
GR  - U54 CA143868/CA/NCI NIH HHS/United States
GR  - U54 CA143868-01/CA/NCI NIH HHS/United States
GR  - T32 CA130840/CA/NCI NIH HHS/United States
GR  - U54 CA143868-03/CA/NCI NIH HHS/United States
GR  - U54 CA143868-02/CA/NCI NIH HHS/United States
GR  - T32 CA153952/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20091130
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Hypoxia-Inducible Factor 1)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/genetics/*metabolism
MH  - Mice
MH  - Neoplasms/genetics/*metabolism/*therapy
PMC - PMC2969168
MID - NIHMS242786
COIS- Conflict of Interest The author declares no conflict of interest.
EDAT- 2009/12/01 06:00
MHDA- 2010/03/03 06:00
PMCR- 2010/11/02
CRDT- 2009/12/01 06:00
PHST- 2009/12/01 06:00 [entrez]
PHST- 2009/12/01 06:00 [pubmed]
PHST- 2010/03/03 06:00 [medline]
PHST- 2010/11/02 00:00 [pmc-release]
AID - onc2009441 [pii]
AID - 10.1038/onc.2009.441 [doi]
PST - ppublish
SO  - Oncogene. 2010 Feb 4;29(5):625-34. doi: 10.1038/onc.2009.441. Epub 2009 Nov 30.