PMID- 19959873
OWN - NLM
STAT- MEDLINE
DCOM- 20100111
LR  - 20240109
IS  - 1558-8238 (Electronic)
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 119
IP  - 12
DP  - 2009 Dec
TI  - Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly 
      controlled type I IFN response.
PG  - 3544-55
LID - 10.1172/JCI40093 [doi]
AB  - African green monkeys (AGMs) infected with the AGM type of SIV (SIVagm) do not 
      develop chronic immune activation and AIDS, despite viral loads similar to those 
      detected in humans infected with HIV-1 and rhesus macaques (RMs) infected with 
      the RM type of SIV (SIVmac). Because chronic immune activation drives progressive 
      CD4+ T cell depletion and immune cell dysfunctions, factors that characterize 
      disease progression, we sought to understand the molecular basis of this AGM 
      phenotype. To this end, we longitudinally assessed the gene expression profiles 
      of blood- and lymph node-derived CD4+ cells from AGMs and RMs in response to 
      SIVagm and SIVmac infection, respectively, using a genomic microarray platform. 
      The molecular signature of acute infection was characterized, in both species, by 
      strong upregulation of type I IFN-stimulated genes (ISGs). ISG expression 
      returned to basal levels after postinfection day 28 in AGMs but was sustained in 
      RMs, especially in the lymph node-derived cells. We also found that SIVagm 
      induced IFN-alpha production by AGM cells in vitro and that low IFN-alpha levels 
      were sufficient to induce strong ISG responses. In conclusion, SIV infection 
      triggered a rapid and strong IFN-alpha response in vivo in both AGMs and RMs, 
      with this response being efficiently controlled only in AGMs, possibly as a 
      result of active regulatory mechanisms.
FAU - Jacquelin, Beatrice
AU  - Jacquelin B
AD  - Institut Pasteur, Unite de Regulation des Infections Retrovirales, Paris, France.
FAU - Mayau, Veronique
AU  - Mayau V
FAU - Targat, Brice
AU  - Targat B
FAU - Liovat, Anne-Sophie
AU  - Liovat AS
FAU - Kunkel, Desiree
AU  - Kunkel D
FAU - Petitjean, Gael
AU  - Petitjean G
FAU - Dillies, Marie-Agnes
AU  - Dillies MA
FAU - Roques, Pierre
AU  - Roques P
FAU - Butor, Cecile
AU  - Butor C
FAU - Silvestri, Guido
AU  - Silvestri G
FAU - Giavedoni, Luis D
AU  - Giavedoni LD
FAU - Lebon, Pierre
AU  - Lebon P
FAU - Barre-Sinoussi, Francoise
AU  - Barre-Sinoussi F
FAU - Benecke, Arndt
AU  - Benecke A
FAU - Muller-Trutwin, Michaela C
AU  - Muller-Trutwin MC
LA  - eng
GR  - P51 RR013986/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Interferon Type I)
RN  - 0 (Interferon-alpha)
SB  - IM
CIN - J Clin Invest. 2009 Dec;119(12):3512-5. PMID: 19959871
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Chlorocebus aethiops
MH  - Gene Expression Profiling
MH  - HIV Infections/immunology/virology
MH  - HIV-1
MH  - Host-Pathogen Interactions/genetics/immunology
MH  - Humans
MH  - Interferon Type I/*biosynthesis/genetics
MH  - Interferon-alpha/biosynthesis/genetics
MH  - Macaca mulatta
MH  - Oligonucleotide Array Sequence Analysis
MH  - Simian Acquired Immunodeficiency Syndrome/genetics/*immunology/virology
MH  - Simian Immunodeficiency Virus/genetics/*immunology/*pathogenicity/physiology
MH  - Species Specificity
MH  - Virulence/immunology
MH  - Virus Replication
PMC - PMC2786805
EDAT- 2009/12/05 06:00
MHDA- 2010/01/12 06:00
PMCR- 2009/11/23
CRDT- 2009/12/05 06:00
PHST- 2009/06/05 00:00 [received]
PHST- 2009/10/19 00:00 [accepted]
PHST- 2009/12/05 06:00 [entrez]
PHST- 2009/12/05 06:00 [pubmed]
PHST- 2010/01/12 06:00 [medline]
PHST- 2009/11/23 00:00 [pmc-release]
AID - 40093 [pii]
AID - 10.1172/JCI40093 [doi]
PST - ppublish
SO  - J Clin Invest. 2009 Dec;119(12):3544-55. doi: 10.1172/JCI40093.