PMID- 19962671
OWN - NLM
STAT- MEDLINE
DCOM- 20091217
LR  - 20220330
IS  - 1878-3686 (Electronic)
IS  - 1535-6108 (Print)
IS  - 1535-6108 (Linking)
VI  - 16
IP  - 6
DP  - 2009 Dec 8
TI  - Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive 
      primitive neuroectodermal brain tumors.
PG  - 533-46
LID - 10.1016/j.ccr.2009.10.025 [doi]
AB  - We discovered a high-level amplicon involving the chr19q13.41 microRNA (miRNA) 
      cluster (C19MC) in 11/45 ( approximately 25%) primary CNS-PNET, which results in 
      striking overexpression of miR-517c and 520g. Constitutive expression of miR-517c 
      or 520g promotes in vitro and in vivo oncogenicity, modulates cell survival, and 
      robustly enhances growth of untransformed human neural stem cells (hNSCs) in part 
      by upregulating WNT pathway signaling and restricting differentiation of hNSCs. 
      Remarkably, the C19MC amplicon, which is very rare in other brain tumors (1/263), 
      identifies an aggressive subgroup of CNS-PNET with distinct gene-expression 
      profiles, characteristic histology, and dismal survival. Our data implicate 
      miR-517c and 520g as oncogenes and promising biological markers for CNS-PNET and 
      provide important insights into oncogenic properties of the C19MC locus.
FAU - Li, Meihua
AU  - Li M
AD  - Division of Hematology-Oncology, Hospital for Sick Children, Toronto, ON M5G 0A3, 
      Canada.
FAU - Lee, Kyle F
AU  - Lee KF
FAU - Lu, Yuntao
AU  - Lu Y
FAU - Clarke, Ian
AU  - Clarke I
FAU - Shih, David
AU  - Shih D
FAU - Eberhart, Charles
AU  - Eberhart C
FAU - Collins, V Peter
AU  - Collins VP
FAU - Van Meter, Tim
AU  - Van Meter T
FAU - Picard, Daniel
AU  - Picard D
FAU - Zhou, Limei
AU  - Zhou L
FAU - Boutros, Paul C
AU  - Boutros PC
FAU - Modena, Piergiorgio
AU  - Modena P
FAU - Liang, Muh-Lii
AU  - Liang ML
FAU - Scherer, Steve W
AU  - Scherer SW
FAU - Bouffet, Eric
AU  - Bouffet E
FAU - Rutka, James T
AU  - Rutka JT
FAU - Pomeroy, Scott L
AU  - Pomeroy SL
FAU - Lau, Ching C
AU  - Lau CC
FAU - Taylor, Michael D
AU  - Taylor MD
FAU - Gajjar, Amar
AU  - Gajjar A
FAU - Dirks, Peter B
AU  - Dirks PB
FAU - Hawkins, Cynthia E
AU  - Hawkins CE
FAU - Huang, Annie
AU  - Huang A
LA  - eng
SI  - GEO/GSE14296
SI  - GEO/GSE16988
GR  - R01 NS055089/NS/NINDS NIH HHS/United States
GR  - P30 HD018655-279002/HD/NICHD NIH HHS/United States
GR  - R01 CA109467-01/CA/NCI NIH HHS/United States
GR  - P30 HD018655/HD/NICHD NIH HHS/United States
GR  - R01 CA109467/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Cell
JT  - Cancer cell
JID - 101130617
RN  - 0 (MicroRNAs)
RN  - 0 (Wnt Proteins)
SB  - IM
EIN - Cancer Cell. 2010 Apr 13;17(4):413
MH  - Animals
MH  - Brain Neoplasms/*genetics/pathology
MH  - Cell Differentiation
MH  - *Chromosomes, Human, Pair 19
MH  - *Gene Amplification
MH  - Humans
MH  - Mice
MH  - MicroRNAs/*genetics
MH  - Neuroectodermal Tumors, Primitive/*genetics/pathology
MH  - Signal Transduction
MH  - Stem Cells
MH  - Wnt Proteins/metabolism
PMC - PMC3431561
MID - NIHMS212642
EDAT- 2009/12/08 06:00
MHDA- 2009/12/18 06:00
PMCR- 2012/08/31
CRDT- 2009/12/08 06:00
PHST- 2009/02/02 00:00 [received]
PHST- 2009/08/03 00:00 [revised]
PHST- 2009/10/23 00:00 [accepted]
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2009/12/18 06:00 [medline]
PHST- 2012/08/31 00:00 [pmc-release]
AID - S1535-6108(09)00388-2 [pii]
AID - 10.1016/j.ccr.2009.10.025 [doi]
PST - ppublish
SO  - Cancer Cell. 2009 Dec 8;16(6):533-46. doi: 10.1016/j.ccr.2009.10.025.