PMID- 20027668
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20220309
IS  - 1098-1128 (Electronic)
IS  - 0198-6325 (Linking)
VI  - 30
IP  - 5
DP  - 2010 Sep
TI  - Curcumin and its analogues: potential anticancer agents.
PG  - 818-60
LID - 10.1002/med.20188 [doi]
AB  - This review chronicles the exploration of the curcumin in terms of development of 
      analogues for the anticancer activity over the last century. Curcumin is a 
      natural phytochemical obtained from dried root and rhizome of Turmeric (Curcuma 
      Longa). It has been shown to interfere with multiple cell signaling pathways, 
      including apoptosis (activation of caspases and downregulation of antiapoptotic 
      gene products), proliferation (HER-2, EGFR, and AP-1), angiogenesis (VEGF), and 
      inflammation (NF-kappaB, TNF, IL-6, IL-1, COX-2, and 5-LOX). In the last decade 
      it has been much explored and various synthetic analogues have been prepared and 
      evaluated for various pharmacological activities. Most of the analogues have 
      shown very good anticancer activity in various models and various cell lines. 
      However, some analogues have also shown antioxidant, anti-HIV, antimutagenic, 
      antiangiogenic, antimalarial, antitubercular, antiandrogenic, COX inhibitory 
      activities. Few analogues have shown very potent results and may be considered as 
      clinical candidates for the development of future anticancer agent. This review 
      contains 728 curcumin analogues and covers the literature from 1815 to mid 2009 
      and 93 references are cited.
CI  - (c) 2009 Wiley Periodicals, Inc.
FAU - Agrawal, Dinesh Kumar
AU  - Agrawal DK
AD  - Agra Public Institute of Technology and Computer Education, Department of 
      Pharmacy, Artoni, Agra, India. agrawaldka@gmail.com
FAU - Mishra, Pushpesh Kumar
AU  - Mishra PK
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Med Res Rev
JT  - Medicinal research reviews
JID - 8103150
RN  - 0 (Antineoplastic Agents)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/chemistry/*pharmacology
MH  - Curcumin/*analogs & derivatives/chemistry/*pharmacology
MH  - Humans
MH  - Structure-Activity Relationship
EDAT- 2009/12/23 06:00
MHDA- 2011/01/29 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - 10.1002/med.20188 [doi]
PST - ppublish
SO  - Med Res Rev. 2010 Sep;30(5):818-60. doi: 10.1002/med.20188.