PMID- 20040737
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20220317
IS  - 1544-0591 (Electronic)
IS  - 0022-0345 (Linking)
VI  - 89
IP  - 2
DP  - 2010 Feb
TI  - Curcumin produces an antihyperalgesic effect via antagonism of TRPV1.
PG  - 170-4
LID - 10.1177/0022034509356169 [doi]
AB  - Curcumin has diverse therapeutic effects, such as anti-inflammatory, 
      anti-oxidant, anti-cancer, and antimicrobial activities. The vanilloid moiety of 
      curcumin is considered important for activation of the transient receptor 
      potential vanilloid 1 (TRPV1), which plays an important role in nociception. 
      However, very little is known about the effects of curcumin on nociception. In 
      the present study, we investigated whether the anti-nociceptive effects of 
      curcumin are mediated via TRPV1 by using nociceptive behavioral studies and in 
      vitro whole-cell patch-clamp recordings in the trigeminal system. Subcutaneous 
      injection of capsaicin in the vibrissa pad area of rats induced thermal 
      hyperalgesia. Intraperitoneally administered curcumin blocked capsaicin-induced 
      thermal hyperalgesia in a dose-dependent manner. Whereas curcumin reduced 
      capsaicin-induced currents in a dose-dependent manner in both trigeminal ganglion 
      neurons and TRPV1-expressing HEK 293 cells, curcumin did not affect heat-induced 
      TRPV1 currents. Taken together, our results indicate that curcumin blocks 
      capsaicin-induced TRPV1 activation and thereby inhibits TRPV1-mediated pain 
      hypersensitivity.
FAU - Yeon, K Y
AU  - Yeon KY
AD  - Dental Research Institute and Department of Physiology, Seoul National 
      University, Yeongeon-Dong Chongno-Ku, Korea.
FAU - Kim, S A
AU  - Kim SA
FAU - Kim, Y H
AU  - Kim YH
FAU - Lee, M K
AU  - Lee MK
FAU - Ahn, D K
AU  - Ahn DK
FAU - Kim, H J
AU  - Kim HJ
FAU - Kim, J S
AU  - Kim JS
FAU - Jung, S J
AU  - Jung SJ
FAU - Oh, S B
AU  - Oh SB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091229
PL  - United States
TA  - J Dent Res
JT  - Journal of dental research
JID - 0354343
RN  - 0 (TRPV Cation Channels)
RN  - 0 (Trpv1 protein, rat)
RN  - IT942ZTH98 (Curcumin)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Animals
MH  - Capsaicin/administration & dosage/pharmacology
MH  - Cell Line
MH  - Curcumin/administration & dosage/pharmacology/*therapeutic use
MH  - Facial Pain/chemically induced/*drug therapy/physiopathology
MH  - Hot Temperature
MH  - Humans
MH  - Hyperalgesia/chemically induced/*drug therapy/physiopathology
MH  - Injections, Intraperitoneal
MH  - Injections, Subcutaneous
MH  - Kidney/cytology/embryology
MH  - Male
MH  - Nociceptors/*drug effects
MH  - Nose
MH  - Patch-Clamp Techniques
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - TRPV Cation Channels/antagonists & inhibitors/*physiology
MH  - Trigeminal Ganglion/cytology/drug effects
EDAT- 2009/12/31 06:00
MHDA- 2010/02/02 06:00
CRDT- 2009/12/31 06:00
PHST- 2009/12/31 06:00 [entrez]
PHST- 2009/12/31 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
AID - 0022034509356169 [pii]
AID - 10.1177/0022034509356169 [doi]
PST - ppublish
SO  - J Dent Res. 2010 Feb;89(2):170-4. doi: 10.1177/0022034509356169. Epub 2009 Dec 
      29.