PMID- 20043902
OWN - NLM
STAT- MEDLINE
DCOM- 20100405
LR  - 20220317
IS  - 1095-564X (Electronic)
IS  - 0012-1606 (Linking)
VI  - 339
IP  - 1
DP  - 2010 Mar 1
TI  - Cdx2 regulates patterning of the intestinal epithelium.
PG  - 155-65
LID - 10.1016/j.ydbio.2009.12.025 [doi]
AB  - Cdx1, Cdx2 and Cdx4 encode homeodomain transcription factors that are involved in 
      vertebral anterior-posterior (AP) patterning. Cdx1 and Cdx2 are also expressed in 
      the intestinal epithelium during development, suggesting a role in this tissue. 
      Intestinal defects have not been reported in Cdx1 null mutants, while Cdx2 null 
      mutants die at embryonic day 3.5 (E3.5), thus precluding assessment of the null 
      phenotype at later stages. To circumvent this latter shortcoming, we have used a 
      conditional Cre-lox strategy to inactivate Cdx2 in the intestinal epithelium. 
      Using this approach, we found that ablation of Cdx2 at E13.5 led to a 
      transformation of the small intestine to a pyloric stomach-like identity, 
      although the molecular nature of the underlying mesenchyme remained unchanged. 
      Further analysis of Cdx1-Cdx2 double mutants suggests that Cdx1 does not play a 
      critical role in the development of the small intestine, at least after E13.5.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Grainger, Stephanie
AU  - Grainger S
AD  - Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth 
      Road, Ottawa, Ontario, Canada.
FAU - Savory, Joanne G A
AU  - Savory JG
FAU - Lohnes, David
AU  - Lohnes D
LA  - eng
PT  - Journal Article
DEP - 20100104
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (CDX2 Transcription Factor)
RN  - 0 (Cdx2 protein, mouse)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Body Patterning/*physiology
MH  - CDX2 Transcription Factor
MH  - Cell Cycle/physiology
MH  - Homeodomain Proteins/*physiology
MH  - In Situ Hybridization
MH  - Intestinal Mucosa/cytology/*embryology
MH  - Mice
MH  - Mice, Knockout
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Transcription Factors/*physiology
EDAT- 2010/01/02 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/01/02 06:00
PHST- 2009/07/27 00:00 [received]
PHST- 2009/12/16 00:00 [revised]
PHST- 2009/12/17 00:00 [accepted]
PHST- 2010/01/02 06:00 [entrez]
PHST- 2010/01/02 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - S0012-1606(09)01441-9 [pii]
AID - 10.1016/j.ydbio.2009.12.025 [doi]
PST - ppublish
SO  - Dev Biol. 2010 Mar 1;339(1):155-65. doi: 10.1016/j.ydbio.2009.12.025. Epub 2010 
      Jan 4.