PMID- 20123905
OWN - NLM
STAT- MEDLINE
DCOM- 20100301
LR  - 20211203
IS  - 1549-5477 (Electronic)
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 24
IP  - 3
DP  - 2010 Feb 1
TI  - Structural insights into the YAP and TEAD complex.
PG  - 235-40
LID - 10.1101/gad.1865810 [doi]
AB  - The Yes-associated protein (YAP) transcriptional coactivator is a key regulator 
      of organ size and a candidate human oncogene inhibited by the Hippo tumor 
      suppressor pathway. The TEAD family of transcription factors binds directly to 
      and mediates YAP-induced gene expression. Here we report the three-dimensional 
      structure of the YAP (residues 50-171)-TEAD1 (residues 194-411) complex, in which 
      YAP wraps around the globular structure of TEAD1 and forms extensive interactions 
      via three highly conserved interfaces. Interface 3, including YAP residues 
      86-100, is most critical for complex formation. Our study reveals the biochemical 
      nature of the YAP-TEAD interaction, and provides a basis for pharmacological 
      intervention of YAP-TEAD hyperactivation in human diseases.
FAU - Li, Ze
AU  - Li Z
AD  - School of Life Sciences, Fudan University, Shanghai 200433, China.
FAU - Zhao, Bin
AU  - Zhao B
FAU - Wang, Ping
AU  - Wang P
FAU - Chen, Fei
AU  - Chen F
FAU - Dong, Zhenghong
AU  - Dong Z
FAU - Yang, Huirong
AU  - Yang H
FAU - Guan, Kun-Liang
AU  - Guan KL
FAU - Xu, Yanhui
AU  - Xu Y
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (TEA Domain Transcription Factors)
RN  - 0 (TEAD1 protein, human)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (YAP1 protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/*chemistry/metabolism
MH  - Amino Acid Sequence
MH  - Binding Sites
MH  - DNA-Binding Proteins/*chemistry/metabolism
MH  - Humans
MH  - Models, Molecular
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/*chemistry/metabolism
MH  - Phosphoproteins/*chemistry/metabolism
MH  - Protein Conformation
MH  - Sequence Alignment
MH  - TEA Domain Transcription Factors
MH  - Trans-Activators/*chemistry/metabolism
MH  - Transcription Factors/*chemistry/metabolism
MH  - YAP-Signaling Proteins
PMC - PMC2811825
EDAT- 2010/02/04 06:00
MHDA- 2010/03/02 06:00
PMCR- 2010/08/01
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/03/02 06:00 [medline]
PHST- 2010/08/01 00:00 [pmc-release]
AID - 24/3/235 [pii]
AID - 10.1101/gad.1865810 [doi]
PST - ppublish
SO  - Genes Dev. 2010 Feb 1;24(3):235-40. doi: 10.1101/gad.1865810.