PMID- 20128048
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20201209
IS  - 1793-6853 (Electronic)
IS  - 0192-415X (Linking)
VI  - 38
IP  - 1
DP  - 2010
TI  - Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and 
      fibrosis in rats.
PG  - 99-111
AB  - Curcumin and saikosaponin A as antioxidants improve antioxidant status. This 
      study investigated the anti-inflammatory and antifibrotic actions of curcumin and 
      saikosaponin A on CCl(4)-induced liver damage. Sprague-Dawley rats were randomly 
      divided into control, CCl(4), CCl(4)+ curcumin (0.005%; CU), CCl(4) + 
      saikosaponin A (0.004%; SS), and CCl(4) + curcumin + saikosaponin A (0.005% + 
      0.004%; CU + SS) groups. Carbon tetrachloride (40% in olive oil) at a dose of 
      0.75 ml/kg was injected intraperitoneally once a week. Curcumin and saikosaponin 
      A were supplemented alone or in combination with diet 1 week before CCl(4) 
      injection for 8 weeks. After 8-week supplementation, histopathological results 
      showed hepatic collagen deposition was significantly reduced in the CU and SS 
      groups, and activated nuclear factor-kappa B expression induced by CCl(4) in the 
      liver was significantly inhibited by curcumin and/or saikosaponin A. Hepatic 
      proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and 
      interleukin-6 were significantly inhibited, and anti-inflammatory cytokine 
      interleukin-10 was significantly increased by supplementation with curcumin 
      and/or saikosaponin A. Additionally, curcumin and/or saikosaponin A significantly 
      reduced the increased levels of hepatic transforming growth factor-beta1 and 
      hydroxyproline after CCl(4) treatment. Therefore, supplementation with curcumin 
      and/or saikosaponin A suppress inflammation and fibrogenesis in rats with 
      CCl(4)-induced liver injury. However, the combination has no additive effects on 
      anti-inflammation and antifibrosis.
FAU - Wu, Shu-Ju
AU  - Wu SJ
AD  - Taipei Medical University, Taiwan.
FAU - Tam, Ka-Wai
AU  - Tam KW
FAU - Tsai, Ya-Hui
AU  - Tsai YH
FAU - Chang, Chun-Chao
AU  - Chang CC
FAU - Chao, Jane C-J
AU  - Chao JC
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 0 (Saponins)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 6SMK8R7TGJ (Oleanolic Acid)
RN  - 9007-34-5 (Collagen)
RN  - CL2T97X0V0 (Carbon Tetrachloride)
RN  - IT942ZTH98 (Curcumin)
RN  - RMB44WO89X (Hydroxyproline)
RN  - UR635J3F00 (saikosaponin D)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/isolation & purification/pharmacology/*therapeutic use
MH  - Bupleurum/chemistry
MH  - Carbon Tetrachloride
MH  - Chemical and Drug Induced Liver Injury/*drug therapy/metabolism
MH  - Collagen/metabolism
MH  - Curcuma/chemistry
MH  - Curcumin/isolation & purification/pharmacology/*therapeutic use
MH  - Cytokines/metabolism
MH  - Dietary Supplements
MH  - Drug Therapy, Combination
MH  - Fibrosis/chemically induced/metabolism/*prevention & control
MH  - Hydroxyproline/metabolism
MH  - Inflammation/chemically induced/metabolism/*prevention & control
MH  - Liver/metabolism
MH  - Male
MH  - NF-kappa B/antagonists & inhibitors
MH  - Oleanolic Acid/*analogs & derivatives/isolation & 
      purification/pharmacology/therapeutic use
MH  - Phytotherapy
MH  - Plant Extracts/chemistry/pharmacology/*therapeutic use
MH  - Plant Roots
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rhizome
MH  - Saponins/isolation & purification/pharmacology/*therapeutic use
MH  - Transforming Growth Factor beta1/metabolism
EDAT- 2010/02/04 06:00
MHDA- 2010/04/23 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
AID - S0192415X10007695 [pii]
AID - 10.1142/S0192415X10007695 [doi]
PST - ppublish
SO  - Am J Chin Med. 2010;38(1):99-111. doi: 10.1142/S0192415X10007695.