PMID- 20211163
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20211203
IS  - 1095-564X (Electronic)
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 341
IP  - 2
DP  - 2010 May 15
TI  - Regulation of cell shape, wing hair initiation and the actin cytoskeleton by 
      Trc/Fry and Wts/Mats complexes.
PG  - 360-74
LID - 10.1016/j.ydbio.2010.02.029 [doi]
AB  - The two NDR kinase family genes in Drosophila are tricornered (trc) and warts 
      (wts). Previous studies on trc have focused on its role in the morphogenesis of 
      extensions of epidermal cells and in dendrite branching and tiling. Studies on 
      wts have focused on its roles as a tumor suppressor, in controlling photoreceptor 
      type and in the maintenance of dendrites. Here we examine and compare the 
      function of these genes in wing cells prior to their terminal differentiation. 
      Mutations in these genes lead to changes in cell shape, cellular levels of 
      F-actin, the timing of differentiation, and the expression of multiple wing hairs 
      and DE-Cadherin. We showed that the effects of wts on all of these processes 
      appear to be mediated by its regulation of the Yorkie transcription factor. We 
      also provide evidence that trc regulates the expression of DE-cadherin and mwh. 
      In addition, we showed that the effects on cell shape and the timing of 
      differentiation appear to be not linked to changes in relative growth rate of 
      cells compared to their neighbors.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Fang, Xiaolan
AU  - Fang X
AD  - Department of Biology, University of Virginia, Charlottesville, VA 22903, USA.
FAU - Adler, Paul N
AU  - Adler PN
LA  - eng
GR  - R01 GM037163/GM/NIGMS NIH HHS/United States
GR  - R01 GM037163-24/GM/NIGMS NIH HHS/United States
GR  - R01 GM053498/GM/NIGMS NIH HHS/United States
GR  - R01 GM053498-08/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100306
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (Actins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Mats protein, Drosophila)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 0 (fry protein, Drosophila)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.- (trc protein, Drosophila)
RN  - EC 2.7.1.- (wts protein, Drosophila)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Actins/*metabolism
MH  - Animals
MH  - *Cell Shape
MH  - Cytoskeleton/*metabolism
MH  - Drosophila Proteins/*metabolism
MH  - Drosophila melanogaster/*embryology
MH  - Protein Kinases/*metabolism
MH  - Protein Serine-Threonine Kinases/*metabolism
MH  - Tumor Suppressor Proteins/metabolism
MH  - Wings, Animal/*metabolism
PMC - PMC2862085
MID - NIHMS193527
EDAT- 2010/03/10 06:00
MHDA- 2010/05/15 06:00
PMCR- 2011/05/15
CRDT- 2010/03/10 06:00
PHST- 2009/08/10 00:00 [received]
PHST- 2010/02/19 00:00 [revised]
PHST- 2010/02/20 00:00 [accepted]
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
PHST- 2011/05/15 00:00 [pmc-release]
AID - S0012-1606(10)00138-7 [pii]
AID - 10.1016/j.ydbio.2010.02.029 [doi]
PST - ppublish
SO  - Dev Biol. 2010 May 15;341(2):360-74. doi: 10.1016/j.ydbio.2010.02.029. Epub 2010 
      Mar 6.