PMID- 20223988
OWN - NLM
STAT- MEDLINE
DCOM- 20100325
LR  - 20220408
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 327
IP  - 5971
DP  - 2010 Mar 12
TI  - Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the 
      skin.
PG  - 1385-9
LID - 10.1126/science.1184733 [doi]
AB  - Mammalian epidermis consists of three self-renewing compartments: the hair 
      follicle, the sebaceous gland, and the interfollicular epidermis. We generated 
      knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene. 
      Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair 
      follicles, Lgr6+ cells resided in a previously uncharacterized region directly 
      above the follicle bulge. They expressed none of the known bulge stem cell 
      markers. Prenatal Lgr6+ cells established the hair follicle, sebaceous gland, and 
      interfollicular epidermis. Postnatally, Lgr6+ cells generated sebaceous gland and 
      interfollicular epidermis, whereas contribution to hair lineages gradually 
      diminished with age. Adult Lgr6+ cells executed long-term wound repair, including 
      the formation of new hair follicles. We conclude that Lgr6 marks the most 
      primitive epidermal stem cell.
FAU - Snippert, Hugo J
AU  - Snippert HJ
AD  - Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and 
      University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.
FAU - Haegebarth, Andrea
AU  - Haegebarth A
FAU - Kasper, Maria
AU  - Kasper M
FAU - Jaks, Viljar
AU  - Jaks V
FAU - van Es, Johan H
AU  - van Es JH
FAU - Barker, Nick
AU  - Barker N
FAU - van de Wetering, Marc
AU  - van de Wetering M
FAU - van den Born, Maaike
AU  - van den Born M
FAU - Begthel, Harry
AU  - Begthel H
FAU - Vries, Robert G
AU  - Vries RG
FAU - Stange, Daniel E
AU  - Stange DE
FAU - Toftgard, Rune
AU  - Toftgard R
FAU - Clevers, Hans
AU  - Clevers H
LA  - eng
SI  - GEO/GSE20269
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Lgr5 protein, mouse)
RN  - 0 (Lgr6 protein, mouse)
RN  - 0 (Receptors, G-Protein-Coupled)
SB  - IM
MH  - Animals
MH  - *Cell Lineage
MH  - Epidermal Cells
MH  - Gene Expression Profiling
MH  - Gene Knock-In Techniques
MH  - Hair/cytology/embryology/growth & development
MH  - Hair Follicle/*cytology/embryology/growth & development
MH  - Mice
MH  - Mice, Nude
MH  - Receptors, G-Protein-Coupled/*genetics/*metabolism
MH  - Sebaceous Glands/cytology
MH  - Signal Transduction
MH  - Skin/*cytology
MH  - Stem Cell Transplantation
MH  - Stem Cells/*cytology/metabolism
MH  - Wound Healing
EDAT- 2010/03/13 06:00
MHDA- 2010/03/26 06:00
CRDT- 2010/03/13 06:00
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2010/03/26 06:00 [medline]
AID - 327/5971/1385 [pii]
AID - 10.1126/science.1184733 [doi]
PST - ppublish
SO  - Science. 2010 Mar 12;327(5971):1385-9. doi: 10.1126/science.1184733.