PMID- 20231381
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20220410
IS  - 1540-8140 (Electronic)
IS  - 0021-9525 (Print)
IS  - 0021-9525 (Linking)
VI  - 188
IP  - 6
DP  - 2010 Mar 22
TI  - Targeting of drugs and nanoparticles to tumors.
PG  - 759-68
LID - 10.1083/jcb.200910104 [doi]
AB  - The various types of cells that comprise the tumor mass all carry molecular 
      markers that are not expressed or are expressed at much lower levels in normal 
      cells. These differentially expressed molecules can be used as docking sites to 
      concentrate drug conjugates and nanoparticles at tumors. Specific markers in 
      tumor vessels are particularly well suited for targeting because molecules at the 
      surface of blood vessels are readily accessible to circulating compounds. The 
      increased concentration of a drug in the site of disease made possible by 
      targeted delivery can be used to increase efficacy, reduce side effects, or 
      achieve some of both. We review the recent advances in this delivery approach 
      with a focus on the use of molecular markers of tumor vasculature as the primary 
      target and nanoparticles as the delivery vehicle.
FAU - Ruoslahti, Erkki
AU  - Ruoslahti E
AD  - Vascular Mapping Center, Sanford-Burnham Medical Research Institute, University 
      of California, Santa Barbara, Santa Barbara, CA 93106, USA. ruoslahti@burnham.org
FAU - Bhatia, Sangeeta N
AU  - Bhatia SN
FAU - Sailor, Michael J
AU  - Sailor MJ
LA  - eng
GR  - U54 CA119335/CA/NCI NIH HHS/United States
GR  - U54 CA-119335/CA/NCI NIH HHS/United States
GR  - Howard Hughes Medical Institute/United States
GR  - U54 CA119349/CA/NCI NIH HHS/United States
GR  - CA-122427/CA/NCI NIH HHS/United States
GR  - U54 CA-119349/CA/NCI NIH HHS/United States
GR  - R01 CA124427/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20100315
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Drug Carriers)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Animals
MH  - Biomarkers, Tumor/metabolism
MH  - Drug Carriers/metabolism/pharmacokinetics
MH  - *Drug Delivery Systems
MH  - Humans
MH  - *Nanoparticles
MH  - Neoplasms/blood supply/*drug therapy/*metabolism
MH  - Pharmaceutical Preparations/*metabolism
PMC - PMC2845077
EDAT- 2010/03/17 06:00
MHDA- 2010/04/23 06:00
PMCR- 2010/09/22
CRDT- 2010/03/17 06:00
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
PHST- 2010/09/22 00:00 [pmc-release]
AID - jcb.200910104 [pii]
AID - 200910104 [pii]
AID - 10.1083/jcb.200910104 [doi]
PST - ppublish
SO  - J Cell Biol. 2010 Mar 22;188(6):759-68. doi: 10.1083/jcb.200910104. Epub 2010 Mar 
      15.