PMID- 2027027
OWN - NLM
STAT- MEDLINE
DCOM- 19910607
LR  - 20190724
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 101
IP  - 1
DP  - 1991 Jan
TI  - Immunocytochemical study of macrophages and microglial cells and extracellular 
      matrix components in human CNS disease. 1. Gliomas.
PG  - 47-58
AB  - We have used an immunocytochemical approach to investigate the 
      inter-relationships between astrocytes, macrophages and microglia and the 
      extracellular matrix components fibronectin and laminin, in 27 gliomas. Using 
      recently available markers to macrophages and microglia (monoclonals Mac387, KP1 
      and the lectin RCA-1) and antisera to GFAP, fibronectin and laminin, we have 
      described the reactions of these cells and the extracellular matrix. We found 
      RCA-1 to be the superior marker for detecting most macrophages and microglia. 
      There were more macrophages and microglia in high-grade gliomas than in 
      low-grade. RCA-1 also reacted with endothelial cells in normal and reactive brain 
      but showed markedly less affinity for endothelium in an close to gliomas. A 
      possible role for the extracellular matrix in the astrocyte, macrophage and 
      microglial reactions is discussed in the broader context of their role in the 
      immune response.
FAU - Morris, C S
AU  - Morris CS
AD  - University Department of Neuropathology, University of Oxford, U.K.
FAU - Esiri, M M
AU  - Esiri MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Biomarkers)
RN  - 0 (Fibronectins)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Immune Sera)
RN  - 0 (Laminin)
SB  - IM
MH  - Antibodies, Monoclonal
MH  - Astrocytes/*pathology
MH  - Biomarkers
MH  - Brain Neoplasms/*pathology
MH  - Extracellular Matrix/*ultrastructure
MH  - Fibronectins/analysis
MH  - Glial Fibrillary Acidic Protein/analysis
MH  - Glioma/*pathology
MH  - Humans
MH  - Immune Sera
MH  - Immunohistochemistry
MH  - Laminin/analysis
MH  - Macrophages/*pathology
MH  - Mesoderm
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 0022-510X(91)90017-2 [pii]
AID - 10.1016/0022-510x(91)90017-2 [doi]
PST - ppublish
SO  - J Neurol Sci. 1991 Jan;101(1):47-58. doi: 10.1016/0022-510x(91)90017-2.