PMID- 20303295
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20211020
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 32
IP  - 3
DP  - 2010 Mar 26
TI  - Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling 
      ameliorates autoimmune encephalomyelitis.
PG  - 414-25
LID - 10.1016/j.immuni.2010.03.004 [doi]
AB  - Interleukin-17 (IL-17) secreted by T helper 17 (Th17) cells is essential in the 
      development of experimental autoimmune encephalomyelitis (EAE). However, it 
      remains unclear how IL-17-mediated signaling in different cellular compartments 
      participates in the central nervous system (CNS) inflammatory process. We 
      examined CNS inflammation in mice with specific deletion of Act1, a critical 
      component required for IL-17 signaling, in endothelial cells, macrophages and 
      microglia, and neuroectoderm (neurons, astrocytes, and oligodendrocytes). In 
      Act1-deficient mice, Th17 cells showed normal infiltration into the CNS but 
      failed to recruit lymphocytes, neutrophils, and macrophages. Act1 deficiency in 
      endothelial cells or in macrophages and microglia did not substantially impact 
      the development of EAE. However, targeted Act1 deficiency in 
      neuroectoderm-derived CNS-resident cells resulted in markedly reduced severity in 
      EAE. Specifically, Act1-deficient astrocytes showed impaired IL-17-mediated 
      inflammatory gene induction. Thus, astroctyes are critical in IL-17-Act1-mediated 
      leukocyte recruitment during autoimmune-induced inflammation of the CNS.
FAU - Kang, Zizhen
AU  - Kang Z
AD  - Department of Immunology, Cleveland Clinic, Cleveland, OH 44195, USA.
FAU - Altuntas, Cengiz Zubeyir
AU  - Altuntas CZ
FAU - Gulen, Muhammet Fatih
AU  - Gulen MF
FAU - Liu, Caini
AU  - Liu C
FAU - Giltiay, Natalia
AU  - Giltiay N
FAU - Qin, Hongwei
AU  - Qin H
FAU - Liu, Liping
AU  - Liu L
FAU - Qian, Wen
AU  - Qian W
FAU - Ransohoff, Richard M
AU  - Ransohoff RM
FAU - Bergmann, Cornelia
AU  - Bergmann C
FAU - Stohlman, Stephen
AU  - Stohlman S
FAU - Tuohy, Vincent K
AU  - Tuohy VK
FAU - Li, Xiaoxia
AU  - Li X
LA  - eng
GR  - R01 HL098935/HL/NHLBI NIH HHS/United States
GR  - R01 CA140350/CA/NCI NIH HHS/United States
GR  - R01 AI065470/AI/NIAID NIH HHS/United States
GR  - R01 AI065470-05/AI/NIAID NIH HHS/United States
GR  - P01 HL103453/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100318
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Interleukin-17)
RN  - 0 (Traf3ip2 protein, mouse)
SB  - IM
CIN - Immunity. 2010 Mar 26;32(3):302-4. PMID: 20346771
MH  - Adaptor Proteins, Signal Transducing/deficiency/*immunology/metabolism
MH  - Animals
MH  - Astrocytes/*immunology/metabolism
MH  - Cell Survival
MH  - Encephalomyelitis, Autoimmune, 
      Experimental/genetics/*immunology/metabolism/pathology
MH  - Gene Expression Regulation
MH  - Interleukin-17/*immunology
MH  - Macrophages/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - *Signal Transduction
MH  - T-Lymphocytes, Helper-Inducer/cytology/immunology
PMC - PMC3073618
MID - NIHMS193353
EDAT- 2010/03/23 06:00
MHDA- 2010/04/22 06:00
PMCR- 2011/04/11
CRDT- 2010/03/23 06:00
PHST- 2009/08/09 00:00 [received]
PHST- 2010/01/09 00:00 [revised]
PHST- 2010/03/01 00:00 [accepted]
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
PHST- 2011/04/11 00:00 [pmc-release]
AID - S1074-7613(10)00087-7 [pii]
AID - 10.1016/j.immuni.2010.03.004 [doi]
PST - ppublish
SO  - Immunity. 2010 Mar 26;32(3):414-25. doi: 10.1016/j.immuni.2010.03.004. Epub 2010 
      Mar 18.