PMID- 20333681
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20240210
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 128
IP  - 3
DP  - 2011 Feb 1
TI  - Overexpression of LSD1 contributes to human carcinogenesis through chromatin 
      regulation in various cancers.
PG  - 574-86
LID - 10.1002/ijc.25349 [doi]
AB  - A number of histone demethylases have been identified and biochemically 
      characterized, but the pathological roles of their dysfunction in human disease 
      like cancer have not been well understood. Here, we demonstrate important roles 
      of lysine-specific demethylase 1 (LSD1) in human carcinogenesis. Expression 
      levels of LSD1 are significantly elevated in human bladder carcinomas compared 
      with nonneoplastic bladder tissues (p < 0.0001). cDNA microarray analysis also 
      revealed its transactivation in lung and colorectal carcinomas. LSD1-specific 
      small interfering RNAs significantly knocked down its expression and resulted in 
      suppression of proliferation of various bladder and lung cancer cell lines. 
      Concordantly, introduction of exogenous LSD1 expression promoted cell cycle 
      progression of human embryonic kidney fibroblast cells. Expression profile 
      analysis showed that LSD1 could affect the expression of genes involved in 
      various chromatin-modifying pathways such as chromatin remodeling at centromere, 
      centromeric heterochromatin formation and chromatin assembly, indicating its 
      essential roles in carcinogenesis through chromatin modification.
FAU - Hayami, Shinya
AU  - Hayami S
AD  - Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical 
      Science, The University of Tokyo, Minato-ku, Tokyo, Japan.
FAU - Kelly, John D
AU  - Kelly JD
FAU - Cho, Hyun-Soo
AU  - Cho HS
FAU - Yoshimatsu, Masanori
AU  - Yoshimatsu M
FAU - Unoki, Motoko
AU  - Unoki M
FAU - Tsunoda, Tatsuhiko
AU  - Tsunoda T
FAU - Field, Helen I
AU  - Field HI
FAU - Neal, David E
AU  - Neal DE
FAU - Yamaue, Hiroki
AU  - Yamaue H
FAU - Ponder, Bruce A J
AU  - Ponder BA
FAU - Nakamura, Yusuke
AU  - Nakamura Y
FAU - Hamamoto, Ryuji
AU  - Hamamoto R
LA  - eng
GR  - 19275/CRUK_/Cancer Research UK/United Kingdom
GR  - G0900871/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Chromatin)
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA, Neoplasm)
RN  - EC 1.14.11.- (Histone Demethylases)
RN  - EC 1.5.- (KDM1A protein, human)
SB  - IM
MH  - Cell Cycle
MH  - Cell Division
MH  - Cell Line, Tumor
MH  - Chromatin/genetics/*physiology
MH  - DNA, Complementary/genetics
MH  - DNA, Neoplasm/genetics
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Enzymologic
MH  - *Gene Expression Regulation, Neoplastic
MH  - Histone Demethylases/*genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - Neoplasms/enzymology/*genetics
MH  - Oligonucleotide Array Sequence Analysis
MH  - Polymerase Chain Reaction
MH  - Urinary Bladder/cytology/physiology
MH  - Urinary Bladder Neoplasms/*genetics/pathology
EDAT- 2010/03/25 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/03/25 06:00
PHST- 2010/03/25 06:00 [entrez]
PHST- 2010/03/25 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - 10.1002/ijc.25349 [doi]
PST - ppublish
SO  - Int J Cancer. 2011 Feb 1;128(3):574-86. doi: 10.1002/ijc.25349.