PMID- 2033653
OWN - NLM
STAT- MEDLINE
DCOM- 19910627
LR  - 20071114
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 28
IP  - 2
DP  - 1991 Feb
TI  - T-lymphocyte entry into the central nervous system.
PG  - 254-60
AB  - The entry of T-lymphocytes into the parenchyma of the central nervous system is a 
      critical early feature in the pathogenesis of many experimental and spontaneously 
      occurring immune-mediated illnesses. The physiological mechanisms controlling 
      this entry have not been elucidated. This study reports that T-cell entry into 
      the rat CNS appears to be primarily dependent upon the activation state of the 
      lymphocytes; T-lymphoblasts enter the CNS (and all other tissues examined) in an 
      apparently random manner while T cells not in blast phase are excluded. Antigen 
      specificity, MHC compatibility, T-cell phenotype, and T-cell receptor gene usage 
      do not appear related to the ability of cells to enter. This study demonstrates 
      that when T-lymphoblasts are introduced into the circulation they rapidly appear 
      in the CNS tissue. Their concentration in the CNS reaches a peak between 9 and 12 
      hr, and lymphocytes which have entered, exit within 1 to 2 days. Cells capable of 
      reacting with a CNS antigen remain in the tissue or cyclically reenter to 
      initiate inflammation if they are able to recognize their antigen in the correct 
      MHC context. This observation also appears to pertain to the entry of activated T 
      cells into many other tissues, although their concentrations in these non-CNS 
      sites was not quantitated.
FAU - Hickey, W F
AU  - Hickey WF
AD  - Department of Pathology, Washington University School of Medicine, Saint Louis, 
      Missouri 63110.
FAU - Hsu, B L
AU  - Hsu BL
FAU - Kimura, H
AU  - Kimura H
LA  - eng
GR  - NS-27321/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Antigens, CD)
SB  - IM
MH  - Animals
MH  - Antigens, CD/analysis
MH  - Cell Movement
MH  - Central Nervous System/*physiology
MH  - Leukocyte Count
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Spinal Cord/cytology
MH  - T-Lymphocytes/cytology/immunology/*physiology
MH  - Time Factors
EDAT- 1991/02/01 00:00
MHDA- 1991/02/01 00:01
CRDT- 1991/02/01 00:00
PHST- 1991/02/01 00:00 [pubmed]
PHST- 1991/02/01 00:01 [medline]
PHST- 1991/02/01 00:00 [entrez]
AID - 10.1002/jnr.490280213 [doi]
PST - ppublish
SO  - J Neurosci Res. 1991 Feb;28(2):254-60. doi: 10.1002/jnr.490280213.