PMID- 20339029
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20201226
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 328
IP  - 5979
DP  - 2010 May 7
TI  - Induction of lymphoidlike stroma and immune escape by tumors that express the 
      chemokine CCL21.
PG  - 749-52
LID - 10.1126/science.1185837 [doi]
AB  - Tumor manipulation of host immunity is important for tumor survival and invasion. 
      Many cancers secrete CCL21, a chemoattractant for various leukocytes and lymphoid 
      tissue inducer cells, which drive lymphoid neogenesis. CCL21 expression by 
      melanoma tumors in mice was associated with an immunotolerant microenvironment, 
      which included the induction of lymphoid-like reticular stromal networks, an 
      altered cytokine milieu, and the recruitment of regulatory leukocyte populations. 
      In contrast, CCL21-deficient tumors induced antigen-specific immunity. 
      CCL21-mediated immune tolerance was dependent on host rather than tumor 
      expression of the CCL21 receptor, CCR7, and could protect distant, coimplanted 
      CCL21-deficient tumors and even nonsyngeneic allografts from rejection. We 
      suggest that by altering the tumor microenvironment, CCL21-secreting tumors shift 
      the host immune response from immunogenic to tolerogenic, which facilitates tumor 
      progression.
FAU - Shields, Jacqueline D
AU  - Shields JD
AD  - Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, 1015 
      Lausanne, Switzerland.
FAU - Kourtis, Iraklis C
AU  - Kourtis IC
FAU - Tomei, Alice A
AU  - Tomei AA
FAU - Roberts, Joanna M
AU  - Roberts JM
FAU - Swartz, Melody A
AU  - Swartz MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100325
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Ccr7 protein, mouse)
RN  - 0 (Chemokine CCL21)
RN  - 0 (Cytokines)
RN  - 0 (Receptors, CCR7)
SB  - IM
CIN - Science. 2010 May 7;328(5979):697-8. PMID: 20448171
MH  - Animals
MH  - Antigen-Presenting Cells/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Cell Line, Tumor
MH  - Chemokine CCL21/*metabolism
MH  - Cytokines/metabolism
MH  - Disease Progression
MH  - Female
MH  - Immune Tolerance
MH  - Lymph Nodes/immunology
MH  - Lymphoid Tissue/*immunology/pathology
MH  - Melanoma, Experimental/*immunology/*pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neoplasm Transplantation
MH  - RNA Interference
MH  - Receptors, CCR7/metabolism
MH  - Signal Transduction
MH  - Stromal Cells/*immunology/pathology
MH  - T-Lymphocytes/immunology
MH  - T-Lymphocytes, Regulatory/immunology
MH  - *Tumor Escape
EDAT- 2010/03/27 06:00
MHDA- 2010/05/19 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - science.1185837 [pii]
AID - 10.1126/science.1185837 [doi]
PST - ppublish
SO  - Science. 2010 May 7;328(5979):749-52. doi: 10.1126/science.1185837. Epub 2010 Mar 
      25.