PMID- 20339520
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1687-8469 (Electronic)
IS  - 1687-8450 (Print)
IS  - 1687-8450 (Linking)
VI  - 2009
DP  - 2009
TI  - A Combination of Systemic and Intracranial Anti-CD25 Immunotherapy Elicits a 
      Long-Time Survival in Murine Model of Glioma.
PG  - 963037
LID - 10.1155/2009/963037 [doi]
LID - 963037
AB  - Abrogating the suppression of glioma-infiltrating Tregs in the periphery and the 
      central nervous system is essential to successful glioma rejection. We sought to 
      improve the immune response in glioma-bearing mice, by investigating new 
      strategies using the anti-CD25 immunotherapy. We found a complete long-term 
      survival of glioma-bearing mice treated with a combination of systemic and 
      intracranial anti-CD25 mAb immunotherapy as compared to systemic administration 
      of anti-CD25 mAb. In addition, the group of mice that had been cured by the 
      combined anti-CD25 mAb showed long-term survival without late tumor relapse when 
      challenged with the GL261 glioma. The antitumor immune response was investigated 
      by analysis of antitumor immune response (CTL). Results showed that the use of 
      the combined injections of anti-CD25 mAb induced efficient targeting of Tregs 
      expansion inside and outside of the brain and altered Tregs trafficking in the 
      bone marrow and brain areas where antitumor immunity was primed.
FAU - Poirier, Marie-Denise
AU  - Poirier MD
AD  - Laboratory of Immuno-Oncology and Tumor Immunotherapy, Immunology Program, 
      Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, 
      QC, Canada J1H 5N4.
FAU - Haban, Houda
AU  - Haban H
FAU - El Andaloussi, Abdeljabar
AU  - El Andaloussi A
LA  - eng
PT  - Journal Article
DEP - 20100321
PL  - Egypt
TA  - J Oncol
JT  - Journal of oncology
JID - 101496537
PMC - PMC2842970
EDAT- 2009/01/01 00:00
MHDA- 2009/01/01 00:01
PMCR- 2010/03/21
CRDT- 2010/03/27 06:00
PHST- 2009/08/08 00:00 [received]
PHST- 2009/12/21 00:00 [revised]
PHST- 2009/12/29 00:00 [accepted]
PHST- 2010/03/27 06:00 [entrez]
PHST- 2009/01/01 00:00 [pubmed]
PHST- 2009/01/01 00:01 [medline]
PHST- 2010/03/21 00:00 [pmc-release]
AID - 10.1155/2009/963037 [doi]
PST - ppublish
SO  - J Oncol. 2009;2009:963037. doi: 10.1155/2009/963037. Epub 2010 Mar 21.