PMID- 20361945
OWN - NLM
STAT- MEDLINE
DCOM- 20100719
LR  - 20220330
IS  - 1873-2968 (Electronic)
IS  - 0006-2952 (Linking)
VI  - 80
IP  - 5
DP  - 2010 Sep 1
TI  - Notch signaling: emerging molecular targets for cancer therapy.
PG  - 690-701
LID - 10.1016/j.bcp.2010.03.026 [doi]
AB  - The Notch signaling pathway is a highly conserved developmental pathway, which 
      plays a critical role in cell-fate decision, tissue patterning and morphogenesis. 
      There is increasing evidence that this pathway is dysregulated in a variety of 
      malignancies, and can behave as either an oncogene or a tumor suppressor 
      depending upon cell context. This review highlights the current evidence for 
      aberration of the Notch signaling pathway in a wide range of tumors from 
      hematological cancers, such as leukemia and lymphoma through to skin, breast, 
      lung, pancreas, colon and brain tumors. It proposes that the Notch signaling 
      pathway may represent novel therapeutic targets and will be a welcome asset to 
      the cancer therapeutic arena.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Yin, Ling
AU  - Yin L
AD  - Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 
      33136, United States.
FAU - Velazquez, Omaida C
AU  - Velazquez OC
FAU - Liu, Zhao-Jun
AU  - Liu ZJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100331
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Receptors, Notch)
SB  - IM
MH  - Antineoplastic Agents/pharmacology/*therapeutic use
MH  - Humans
MH  - Neoplasms/*drug therapy/metabolism
MH  - Receptors, Notch/drug effects/*metabolism
MH  - *Signal Transduction
RF  - 158
EDAT- 2010/04/07 06:00
MHDA- 2010/07/20 06:00
CRDT- 2010/04/06 06:00
PHST- 2010/01/28 00:00 [received]
PHST- 2010/03/23 00:00 [revised]
PHST- 2010/03/24 00:00 [accepted]
PHST- 2010/04/06 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/07/20 06:00 [medline]
AID - S0006-2952(10)00214-5 [pii]
AID - 10.1016/j.bcp.2010.03.026 [doi]
PST - ppublish
SO  - Biochem Pharmacol. 2010 Sep 1;80(5):690-701. doi: 10.1016/j.bcp.2010.03.026. Epub 
      2010 Mar 31.