PMID- 20364097
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20240419
IS  - 1558-8238 (Electronic)
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 120
IP  - 4
DP  - 2010 Apr
TI  - Making the blastocyst: lessons from the mouse.
PG  - 995-1003
LID - 41229 [pii]
LID - 10.1172/JCI41229 [doi]
AB  - Mammalian preimplantation development, which is the period extending from 
      fertilization to implantation, results in the formation of a blastocyst with 
      three distinct cell lineages. Only one of these lineages, the epiblast, 
      contributes to the embryo itself, while the other two lineages, the trophectoderm 
      and the primitive endoderm, become extra-embryonic tissues. Significant gains 
      have been made in our understanding of the major events of mouse preimplantation 
      development, and recent discoveries have shed new light on the establishment of 
      the three blastocyst lineages. What is less clear, however, is how closely human 
      preimplantation development mimics that in the mouse. A greater understanding of 
      the similarities and differences between mouse and human preimplantation 
      development has implications for improving assisted reproductive technologies and 
      for deriving human embryonic stem cells.
FAU - Cockburn, Katie
AU  - Cockburn K
AD  - Department of Molecular Genetics, University of Toronto, Canada.
FAU - Rossant, Janet
AU  - Rossant J
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100401
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Transcription Factors)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Animals
MH  - Blastocyst/*physiology
MH  - Cell Division
MH  - Cell Lineage
MH  - Cell Polarity
MH  - Embryonic Development
MH  - Endoderm/cytology
MH  - Fibroblast Growth Factors/physiology
MH  - Germ Layers/cytology
MH  - Humans
MH  - Mice
MH  - Stem Cells/cytology
MH  - Transcription Factors/physiology
PMC - PMC2846056
EDAT- 2010/04/07 06:00
MHDA- 2010/04/22 06:00
PMCR- 2010/12/31
CRDT- 2010/04/06 06:00
PHST- 2010/04/06 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
PHST- 2010/12/31 00:00 [pmc-release]
AID - 41229 [pii]
AID - 10.1172/JCI41229 [doi]
PST - ppublish
SO  - J Clin Invest. 2010 Apr;120(4):995-1003. doi: 10.1172/JCI41229. Epub 2010 Apr 1.