PMID- 20370625
OWN - NLM
STAT- MEDLINE
DCOM- 20101026
LR  - 20211020
IS  - 1040-8401 (Print)
IS  - 1040-8401 (Linking)
VI  - 30
IP  - 2
DP  - 2010
TI  - The pathogenesis of murine coronavirus infection of the central nervous system.
PG  - 119-30
AB  - Mouse hepatitis virus (MHV) is a positive-strand RNA virus that causes an acute 
      encephalomyelitis that later resolves into a chronic fulminating demyelinating 
      disease. Cytokine production, chemokine secretion, and immune cell infiltration 
      into the central nervous system are critical to control viral replication during 
      acute infection. Despite potent antiviral T-lymphocyte activity, sterile immunity 
      is not achieved, and MHV chronically persists within oligodendrocytes. Continued 
      infiltration and activation of the immune system, a result of the lingering viral 
      antigen and RNA within oligodendrocytes, lead directly to the development of an 
      immune-mediated demyelination that bears remarkable similarities, both clinically 
      and histologically, to the human demyelinating disease multiple sclerosis. MHV 
      offers a unique model system for studying host defense during acute viral 
      infection and immune-mediated demyelination during chronic infection.
FAU - Lane, Thomas E
AU  - Lane TE
AD  - Department of Molecular Biology and Biochemistry, University of California, 
      Irvine, California 92697-3900, USA.
FAU - Hosking, Martin P
AU  - Hosking MP
LA  - eng
GR  - NS41249/NS/NINDS NIH HHS/United States
GR  - T32 AI060573/AI/NIAID NIH HHS/United States
GR  - R01 NS041249/NS/NINDS NIH HHS/United States
GR  - R01 NS041249-08/NS/NINDS NIH HHS/United States
GR  - T32 AI-060573./AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Crit Rev Immunol
JT  - Critical reviews in immunology
JID - 8914819
SB  - IM
MH  - Animals
MH  - Central Nervous System Viral Diseases/*immunology/pathology/*virology
MH  - Coronavirus Infections/*immunology/*virology
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - Multiple Sclerosis/pathology
MH  - Murine hepatitis virus/*immunology/*pathogenicity
PMC - PMC2852265
MID - NIHMS156933
EDAT- 2010/04/08 06:00
MHDA- 2010/10/27 06:00
PMCR- 2010/04/09
CRDT- 2010/04/08 06:00
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/10/27 06:00 [medline]
PHST- 2010/04/09 00:00 [pmc-release]
AID - 5603dbb41ca52347,09e37c0900ab77b6 [pii]
AID - 10.1615/critrevimmunol.v30.i2.20 [doi]
PST - ppublish
SO  - Crit Rev Immunol. 2010;30(2):119-30. doi: 10.1615/critrevimmunol.v30.i2.20.