PMID- 20370702
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20220321
IS  - 1875-5607 (Electronic)
IS  - 1389-5575 (Print)
IS  - 1389-5575 (Linking)
VI  - 10
IP  - 5
DP  - 2010 May
TI  - Perspectives on chemopreventive and therapeutic potential of curcumin analogs in 
      medicinal chemistry.
PG  - 372-87
AB  - Curcumin is a natural polyphenol derived from the plant Curcuma longa, commonly 
      called turmeric. Extensive research over past 50 years has indicated that this 
      polyphenol is highly pleiotropic molecule capable of preventing and treating 
      various cancers. The anticancer potential of Curcumin is severely affected by its 
      limited systemic and target tissue bioavailability and rapid metabolism. In the 
      present review article, we provide a summarized account of different drug 
      delivery systems employed for tackling the problem of cucumin's bioavailability 
      such as liposomes, phospholipid complexes and nanoparticles. Concomitantly we 
      have reviewed the large volume of literature reports describing structural 
      modifications of Curcumin and the anticancer potential of its analogs. Some of 
      the difluorocurcumin analogs allowing longer circulation times and preferential 
      accumulation in the pancreas seem to offer promising leads for conducting first 
      in-depth animal studies and subsequently clinical trials for the use of these 
      analogs for prevention of tumor progression and/or treatments of human 
      malignancies.
FAU - Padhye, Subhash
AU  - Padhye S
AD  - Dr. D.Y.Patil University, Pimpri, Pune-411018, India.
FAU - Chavan, Deepak
AU  - Chavan D
FAU - Pandey, Shubhangini
AU  - Pandey S
FAU - Deshpande, Jyoti
AU  - Deshpande J
FAU - Swamy, K Venkateswara
AU  - Swamy KV
FAU - Sarkar, Fazlul H
AU  - Sarkar FH
LA  - eng
GR  - R01CA131151/CA/NCI NIH HHS/United States
GR  - R01 CA131151/CA/NCI NIH HHS/United States
GR  - 5P20-CA101936/CA/NCI NIH HHS/United States
GR  - P20 CA101936/CA/NCI NIH HHS/United States
GR  - R01CA132794/CA/NCI NIH HHS/United States
GR  - R01CA083695/CA/NCI NIH HHS/United States
GR  - R01 CA131151-04/CA/NCI NIH HHS/United States
GR  - R01 CA132794/CA/NCI NIH HHS/United States
GR  - R01 CA083695/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Mini Rev Med Chem
JT  - Mini reviews in medicinal chemistry
JID - 101094212
RN  - 0 (Anticarcinogenic Agents)
RN  - 0 (Antineoplastic Agents)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Anticarcinogenic Agents/chemistry
MH  - Antineoplastic Agents/administration & dosage/*chemistry/pharmacokinetics
MH  - Curcuma/chemistry
MH  - Curcumin/administration & dosage/*chemistry/pharmacokinetics
MH  - Drug Delivery Systems
MH  - Humans
MH  - Models, Molecular
MH  - Neoplasms/drug therapy/prevention & control
MH  - Rats
PMC - PMC3084451
MID - NIHMS290167
EDAT- 2010/04/08 06:00
MHDA- 2010/08/19 06:00
PMCR- 2011/04/29
CRDT- 2010/04/08 06:00
PHST- 2010/03/11 00:00 [received]
PHST- 2010/03/12 00:00 [accepted]
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
PHST- 2011/04/29 00:00 [pmc-release]
AID - MRMC Epub-117 [pii]
AID - 10.2174/138955710791330891 [doi]
PST - ppublish
SO  - Mini Rev Med Chem. 2010 May;10(5):372-87. doi: 10.2174/138955710791330891.