PMID- 20381955
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20240312
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 296
IP  - 1
DP  - 2010 Oct 1
TI  - Novel in vivo model of inducible multi-drug resistance in acute lymphoblastic 
      leukemia with chromosomal translocation t(4;11).
PG  - 49-54
LID - 10.1016/j.canlet.2010.03.017 [doi]
AB  - Acute lymphoblastic leukemia (ALL) with translocation t(4;11) is found in 60-85% 
      of infants with ALL and is often refractory to conventional chemotherapeutics 
      after relapse. Using the t(4;11) ALL line SEM, we evaluated chemotherapy 
      resistance in NOD.CB17-Prkdcscid/J mice. SEM cells were injected into the tail 
      vein and engraftment was monitored by flow cytometry. Once engraftment was 
      observed, mice were injected intraperitoneally with phosphate-buffered saline 
      (PBS), or vincristine (0.5mg/kg body weight) three times per week for 4weeks (n=8 
      per group). The level of P-glycoprotein in SEM cells was increased 3-fold by 
      vincristine treatment compared to PBS-treated mice. Survival curves showed that 
      leukemia cell growth was initially delayed by vincristine treatment, but the mice 
      eventually succumbed to disease. These data describe a novel inducible model for 
      investigating multi-drug resistance mechanisms in high-risk t(4;11) ALL.
CI  - Published by Elsevier Ireland Ltd.
FAU - Zunino, Susan J
AU  - Zunino SJ
AD  - United States Department of Agriculture, Agricultural Research Service, Western 
      Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, 
      United States. susan.zunino@ars.usda.gov
FAU - Storms, David H
AU  - Storms DH
FAU - Ducore, Jonathan M
AU  - Ducore JM
LA  - eng
GR  - R21 CA122117/CA/NCI NIH HHS/United States
GR  - 1R21CA122117-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100409
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (UCHL1 protein, human)
RN  - 5J49Q6B70F (Vincristine)
RN  - EC 3.4.19.12 (Ubiquitin Thiolesterase)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Cell Death/drug effects
MH  - Cell Line, Tumor
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 4
MH  - Crosses, Genetic
MH  - Drug Resistance, Multiple/*genetics
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Mice, SCID
MH  - Neoplasm Transplantation
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/*genetics/pathology
MH  - Translocation, Genetic/*genetics
MH  - Ubiquitin Thiolesterase/genetics
MH  - Vincristine/therapeutic use
PMC - PMC2906616
MID - NIHMS195255
COIS- Conflict of Interest Statement No conflict of interest for any of the authors.
EDAT- 2010/04/13 06:00
MHDA- 2010/08/11 06:00
PMCR- 2011/10/01
CRDT- 2010/04/13 06:00
PHST- 2010/01/22 00:00 [received]
PHST- 2010/03/12 00:00 [revised]
PHST- 2010/03/22 00:00 [accepted]
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
PHST- 2011/10/01 00:00 [pmc-release]
AID - S0304-3835(10)00167-9 [pii]
AID - 10.1016/j.canlet.2010.03.017 [doi]
PST - ppublish
SO  - Cancer Lett. 2010 Oct 1;296(1):49-54. doi: 10.1016/j.canlet.2010.03.017. Epub 
      2010 Apr 9.